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Davante Adams of the Las Vegas Raiders scores a touchdown against the Arizona Cardinals at Allegiant Stadium on Sept. 18, 2022 in Las Vegas, Nevada.
Davante Adams of the Las Vegas Raiders scores a touchdown against the Arizona Cardinals at Allegiant Stadium on Sept. 18, 2022 in Las Vegas, Nevada. Photo by Chris Unger/Getty Images via AFP.

The Indianapolis Colts look to rebound from three straight losses when they meet the lowly Las Vegas Raiders. Here are our top picks as the 2-6 Raiders host the 3-5-1 Colts in Week 10.

Hopes were high for Raiders nation following the blockbuster offseason trade for wideout Davante Adams, but his old college connection with quarterback Derek Carr has been inconsistent at best. Injuries have played a factor as well, with very few snaps featuring Carr, Adams, wideout Hunter Renfrow, and tight end Darren Waller on the field together. 

The Colts haven’t dealt with as many injuries, but poor performances from key players have been just as apparent during their current losing streak. Starting QB Matt Ryan was benched for Sam Ehlinger after losing to the Tennessee Titans in Week 7, and the offense is in disarray since subsequent firings of offensive coordinator Marcus Brady and head coach Frank Reich. Can Indianapolis convert in a plus-matchup against Vegas?

Here are our top Colts-Raiders Week 10 NFL picks (odds via Caesars Sportsbook and DraftKings Sportsbook; pick confidence based on a 1-to-5-star scale).

Check out all of our NFL picks for Week 10, along with our best bets and touchdown scorer props.

Colts vs. Raiders Game Info

  • Date: Sunday, Nov. 13, 4:05 p.m. ET
  • TV: CBS
  • Location: Allegiant Stadium, Las Vegas, NV
  • Weather: 60 degrees, 2% chance of precipitation, 12-mph winds

Colts vs. Raiders Odds

Colts vs. Raiders Odds Analysis

The Over/Under opened at 43 but has since slipped to its current total of 40.5 as of Friday afternoon, with 61% of the tickets and 87% of the cash still counting on the Under. If you believe the Under will hit, wager with Caesars Sportsbook as they're offering similar odds but at a slightly higher total of 42, compared to DraftKings and FanDuel.

The Raiders opened as 3.5-point favorites, but the spread has since rose to -4.5. Caesars also offers a different spread of Raiders -6, but there's little benefit to that discrepancy in this market.

Colts vs. Raiders Picks

  • Spread: Raiders -4.5 (-110 via Caesars) ★★★★★
  • Over/Under: Under 41 (-110 via Caesars) ★★★★★
  • Prop: Davante Adams 2+ touchdowns (+500 via DraftKings) ★★★★

Colts vs. Raiders ATS Pick

Raiders -4.5 (-110) ★★★★★

The Raiders weren’t exactly a playoff juggernaut heading into this season, but disappointment has followed them all the same. The offense has rolled along just fine despite being banged up, with the defense the real culprit for their 2-6 record. Las Vegas held a multi-possession lead before ultimately losing in three different games so far, meaning they could be 5-3 if things shaked out differently.

Luckily, they’re in good position to bounce back against a Colts team that averaged less than 10 points per game during their current three-game losing streak. The Raiders are a surprisingly decent home team as well, with a 2-1 record at Allegiant Stadium despite being 2-6 overall. A potentially lesser opponent with scoring troubles, on home soil, could be just what the doctor ordered.

Colts vs. Raiders O/U Pick

Under 41 (-110) ★★★★★

It’s tough to see a scenario where 43+ points are scored in this contest, especially since Indianapolis struggled to even hit double digits in recent weeks. Not to mention it gets worse on the road, as the Colts scored three, 10, and 12 points in their last three away games. Their 14.7 PPG is unsurprisingly the league's worst, and bodes well for a Raiders team allowing just north of 25 PPG.

On the offensive side of the ball, the aforementioned Renfrow and Waller injuries complicate things for Vegas. Fortunately, Adams and wide receiver Mack Hollins can shoulder a lot of the load, and running back Josh Jacobs has been dynamic at moving the ball downfield. Indianapolis only gives up 20.3 PPG, so their defensive prowess combined with their inability to score with regularity should keep this total Under.

Colts vs. Raiders Prop Pick

Adams 2+ touchdowns (+500) ★★★★

Taking a chance on a multi-touchdown prop is usually not worthwhile, but it’s hard to ignore when the news just keeps funneling more targets Adams' way with each passing day. He had a pair of touchdown games in the past month alone – including just last week. The 17 targets he saw last week aren't a far cry from the volume he'll regularly see now, either.

When the Raiders are in the redzone, they look towards one man to get the job done. Even in double-coverage, Adams is enough of a freak to find a way. Of 26 redzone targets Carr dished out this year, 13 have gone to Adams. This level of talent married to that kind of pay dirt equity make this prop one to seriously consider – especially at such favorable odds.  

Where to Bet on Colts vs. Raiders Picks

Here are our top-rated sportsbooks:

Colts-Raiders picks made 11/11/2022 at 12:11 p.m. ET