Bills vs. Rams Expert Picks for MNF: Monday Night Football Predictions
A clash of two teams with Super Bowl aspirations wraps up Week 5 NFL action and our Bills vs. Rams expert picks will you have all set for Monday Night Football.
The Rams are a 3.5-point betting favorite ahead of kickoff from SoFi Stadium in Inglewood, Calif., at 8:15 p.m. ET. You can catch all the action on ESPN or ABC. Read on to see whether our experts think it could be two losses in a row for the visitors from New York.
Bills vs. Rams expert picks: Monday Night Football
See all of our experts' NFL picks based on the latest NFL odds.
| Expert | Pick |
|---|---|
| Mike Spector | Rams -3.5 (-102) |
| Brenden Schaeffer | Kyren Williams Over 19.5 receiving yards (-114) |
| Philip Wood | Puka Nacua anytime touchdown scorer (-120) |
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Mike Spector's pick: Rams -3.5 (-102)
The Rams’ pass-catching duo of Puka Nacua and Davante Adams should cause Buffalo fits, especially if cornerbacks Dee Alford (ankle) and Christian Benford (toe) remain out or are limited. Nacua has also proven he is capable of going off in this head-to-head matchup, as he turned in a 12/162/1 stat line against Buffalo in 2024.
See Mike Spector full analysis in his Bills vs. Rams prediction.
Brenden Schaeffer's pick: Kyren Williams Over 19.5 receiving yards (-114)
Williams has 173 receiving yards through four games, clearing this line in three of the four contests. He faces a Bills defense that has allowed 40.5 receiving yards per game to RBs (sixth-most in NFL).
It's not all pro-Rams in Brenden Schaeffer Bills vs. Rams same-game parlay, there's an anti-Bills play, too.
Philip Wood's pick: Puka Nacua anytime touchdown scorer (-120)
The Bills rank 30th in passing yards allowed per game, and despite playing one fewer game than almost every team in the NFL, the Bills enter Monday Night Football allowing the sixth-most passing touchdowns.
There is a Bills play in Philip Wood's Bills vs. Rams touchdown scorer predictions - and it's a +2200 ticket!
How to watch Bills vs. Rams: Monday Night Football
- Date: Monday, Oct. 12
- Kickoff: 8:15 p.m. ET
- Location: SoFi Stadium (Inglewood, Calif.)
- TV: ESPN/ABC
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