NFL Odds & Week 6 Schedule | Betting Lines, Spreads and Totals for Every Game
NFL odds Week 6, 2026
The NFL odds for Week 6 are via bet365.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Seahawks vs. Broncos (TNF) | Seahawks -3 | SEA -155 / DEN +130 | 41.5 |
| Texans vs. Jaguars (in London) | Jaguars -2.5 | HOU +128 / JAX -153 | 43.5 |
| Ravens vs. Browns | Ravens -3.5 | BAL -220 / CLE +180 | 40.5 |
| Panthers vs. Eagles | Eagles -1.5 | CAR +105 / PHI -125 | 42.5 |
| Bears vs. Falcons | Bears -3.5 | CHI -185 / ATL +155 | 47.5 |
| Saints vs. Giants | Giants -1.5 | NO -105 / NYG -115 | 45.5 |
| Jets vs. Patriots | Patriots -7.5 | NYJ +290 / NE -370 | 44.5 |
| Steelers vs. Buccaneers | Steelers -2.5 | PIT -150 / TB +125 | 40.5 |
| Titans vs. Colts | Colts -6.5 | TEN +260 / IND -320 | 43.5 |
| Cardinals vs. Rams | Rams -12.5 | ARI +475 / LAR -650 | 52.5 |
| Bills vs. Raiders | Bills -5.5 | BUF -275 / LV +225 | 52.5 |
| Chargers vs. Chiefs | Chiefs -8.5 | LAC +310 / KC -390 | 43.5 |
| Cowboys vs. Packers (SNF) | Packers -1.5 | DAL -106 / GB -114 | 52.5 |
| Commanders vs. 49ers (MNF) | 49ers -7.5 | WSH +330 / SF -420 | 50.5 |
Our NFL picks will be locked and loaded for Week 6 as bye weeks and London games roll on.
- Thursday Night Football kicks off with the Seahawks as 3-point road favorites in Denver at Mile High; kickoff at 8:15 p.m. ET (Prime Video)
- A third straight London game opens Sunday as the Jaguars (-2.5) and Tebut ixans clash at Wembley Stadium; kickoff at 9:30 a.m. ET (NFL Network)
- Two historical powerhouses battle on Sunday Night Football as the Packers (-1.5) host the Cowboys; kickoff from Lambeau Field at 8:20 p.m. ET (NBC)
- One of the Super Bowl odds favorites close the week when the 49ers (-7.5) host the Commanders on Monday Night Football; kickoff from Levi's Stadium is at 8:15 p.m. ET (ESPN/ABC)
- Four teams are on the sidelines, with the Cincinnati Bengals (3-2), Detroit Lions (3-2), Miami Dolphins (0-5), and Minnesota Vikings (5-0) on bye
Seahawks vs. Broncos: Thursday Night Football
- Kickoff: 8:15 p.m. ET from Empower Field at Mile High (Denver)
- How to watch: Prime Video
Texans vs. Jaguars in London
- Kickoff: 9:30 a.m. ET from Wembley Stadium (London)
- How to watch: NFL Network
Cowboys vs. Packers: Sunday Night Football
- Kickoff: 8:20 p.m. ET from Lambeau Field (Green Bay, Wis.)
- How to watch: NBC
Commanders vs. 49ers: Monday Night Football
- Kickoff: 8:15 p.m. ET from Levi's Stadium (Santa Clara, Calif.)
- How to watch: ESPN/ABC
NFL Week 6 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line with your NFL predictions. The closer you wait until kickoff to make your picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
Who's playing on prime time in Week 6?
We have a fourth prime-time game in Week 6, joining Thursday Night Football, Sunday Night Football, and Monday Night Football. The NFL International Series continues with a standalone game on Sunday morning in London: the Texans vs. the Jaguars.
The week opens with a showdown between the Broncos and visiting Seahawks on Thursday Night Football. Sunday wraps up with the Cowboys vs. Packers in a clash of America's favorite teams on Sunday Night Football. The 14-game slate finishes with the Commanders vs. the 49ers on Monday Night Football.
📃 Affiliate disclosure
Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)
Related Articles
