Pacers vs. Cavaliers Prediction: Game 1 Odds & Expert Picks

Our Pacers vs. Cavaliers prediction for Game 1 is looking toward a strong series-opening game for Cleveland, with momentum building.
Pacers vs. Cavaliers Prediction
Pictured: Cleveland Cavaliers guard Donovan Mitchell celebrates during the second half against the Detroit Pistons. Photo by Rick Osentoski / Imagn.

Though we don’t expect an appearance from John Haliburton, the Indiana Pacers will be at Rocket Arena in Cleveland for Game 1 of their NBA playoffs series against the Cavaliers on Sunday at 6 p.m. ET (TNT), and we're making our Pacers vs. Cavaliers prediction.

Our expert picks based on the betting odds from the best NBA betting sites envision a fast start for the Cavs. After Cleveland demolished the Heat in four straight games, our prediction views any single-digit spread as insufficient to contain the Cavaliers’ explosive offense as part of our NBA picks.  

The Cavaliers enter Game 1 as 8-point betting favorites, with moneyline odds around -325. The total is set at 229.5.

💰 Pacers vs. Cavaliers expert picks for Game 1

🔎 Our NEW NBA player prop odds tool can help you find the best NBA odds across legal sportsbooks in your area!

✅ Against the spread pick: Cavaliers -8 (-105 via Caesars) ⭐⭐⭐⭐
✅ Moneyline pick: Cavaliers (-325 via
DraftKings) ⭐⭐⭐
✅ Over/Under pick: Over 229 (-108 via
FanDuel) ⭐⭐⭐⭐

🏀 Game 1 prediction & best bet

🎯 Score prediction: Cavaliers 124, Pacers 110

With Cleveland and Indiana both ranking among the league’s top-10 scoring units on a points per game basis, Over 229 is an intriguing play on Sunday night at Rocket Arena. But for our best bet in this matchup, we’re leaning into the Eastern Conference’s top unit against the spread this season.

The Cavaliers are 51-34-1 against the spread, ranking second in the NBA this season. Cleveland’s average margin of victory at home is 11.7, and the Cavs are fresh off a four-game sweep of the Heat. They dominated each outing while covering this spread every time, which has dipped from its opening line of -8.5 down to -8 at several of our best sports betting sites.

The last time we saw the Cavaliers, they were completing an eye-popping 55-point win to clinch the first-round series in Miami. Cleveland’s prowess offensively has led to an average of 126.0 points per game so far in these NBA playoffs.

The Pacers bested the Cavs in overtime during their final regular-season meeting, so we’re looking for Cleveland’s focus to be on another level as it opens up this next series. Indiana is just 20-23 ATS as a road team this season.

✅ Best bet: Cavaliers -8 (-105 via Caesars)

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📈 Pacers vs. Cavaliers odds

Live updated odds from our best sports betting sites.

🪧 Game 1 opening odds

Opening odds via BetMGM.

  • Spread: Pacers +8.5 (-115) | Cavaliers -8.5 (-105)
  • Moneyline: Pacers +275 | Cavaliers -350
  • Over/Under: Over 229.5 (-110) | Under 229.5 (-110)

🚑 Pacers vs. Cavaliers injury report

Follow the official NBA injury report for more injury news.

📡 How to watch Pacers vs. Cavaliers live (Game 1)

📅 Sunday, May 4
🕗 6 p.m. ET
📍 Rocket Arena (Cleveland)
📺 TNT | 🛜 Max and Fubo

💵 Best NBA betting sites

Ready to bet on the NBA playoffs? Check out the best NBA betting sites and best sportsbook promos for today's games:

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