Roughriders vs. Lions Prediction & Odds: CFL Week 17 Picks for Friday, Sept. 25
Last Updated: September 25, 2026 10:00 AM EDT • 2 minute read X Social Google News Link
📡 SBR Edge: Lions' Offense Keeps Rolling
My Roughriders vs. Lions prediction includes Lions -3.5 (+100) and Over 62.5 (-105). BC is averaging 16.4 more points per game than Saskatchewan over its last five games, which should help both bets cash.
🏈 Roughriders vs. Lions prediction: CFL picks
See all of our experts' CFL picks based on the latest CFL odds.
| Pick | Bet size | Notes |
|---|---|---|
| Lions -3.5 (+100 via DraftKings) | 2 units to win 2 units | The Lions are averaging 16.4 more points per game than the Roughriders over their last 5 games. |
| Over 62.5 (-105 via FanDuel) | 0.53 units to win 0.5 units | The Lions have scored 45+ points in 2 of their last 3 games. |
Total wagered: 2.53 units | Max profit: +2.5 units
📃 Affiliate disclosure
Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)
💰 Roughriders vs. Lions prediction & best bet
Lions -3.5 (+100 via DraftKings)
The defending champion Roughriders are a 3.5-point underdog against a team with a worse record than them.
I would love to say "Vegas knows" - not actually, because I don't believe in that stuff - but the fact of the matter is that the Lions have just been much better than the Roughriders lately. BC is averaging 16.4 more points per game than Saskatchewan over its last five games and is coming off a 19-point win over the Alouettes, the betting favorite in the Grey Cup odds.
Lions -3.5 (+100 via DraftKings) is the best line available among the top sports betting apps.
Score prediction: Lions 35, Roughriders 28
🚨 Alberta: Sports betting is now live!
Regulated sports betting in Alberta officially launched July 13, allowing sportsbooks to operate under provincial oversight.
To see which sportsbooks are available for betting on your Elks or Stampeders - and how to sign up - see our list of the best Alberta betting apps.
🔥 More Roughriders vs. Lions picks
Over 62.5 (-105 via FanDuel)
It's been hard to justify taking the Under in a Lions game recently. BC has scored 45 or more points in two of its last three games, with the Over going 3-0 in that span.
Nathan Rourke has an outside shot at winning Most Outstanding Player after taking home the award last season and has recorded a quarterback rating of 112.8 or higher in four of his last five games.
The Roughriders' offense has been inconsistent lately, but at this number, BC should be able to do most of the heavy lifting for the Over to hit. Over 62.5 (-105 via FanDuel) is the best line available among the top sports betting sites.
💵 My betting record for CFL picks
All CFL picks have been tracked since June 4.
| Bet type | Record | Net profit | ROI |
|---|---|---|---|
| Overall | 26-26-1 | +3.13 units ✅ | 4.4% ✅ |
| Spreads | 15-11 | +5.9 units ✅ | 10.4% ✅ |
| Totals | 11-15 | -2.78 units ❌ | -19.6% ❌ |
📊 Live Roughriders vs. Lions odds
📈 Roughriders vs. Lions betting trends
| Roughriders | Statistic | Lions |
|---|---|---|
| 8-5 | W-L record | 7-6 |
| 6-7 | ATS record | 6-7 |
| 6-7 | O/U record | 8-5 |
| L, 19-6 @ Blue Bombers | Previous result | W, 48-29 vs. Alouettes |
📺 How to watch Roughriders vs. Lions
- Date: Friday, Sept. 25
- Kickoff: 10:30 p.m. ET
- Location: BC Place (Vancouver)
- TV: TSN, CFL+
Corey Scott X social