Reds vs. Blue Jays Prediction & Picks: MLB Odds for Sunday, Sept. 27
It's the final day of the 2026 MLB regular season, and the Cincinnati Reds will take on the Toronto Blue Jays in an effort to end their disappointing year with some momentum. Brandon Williamson takes on Max Scherzer in this interconference tilt.
My Reds vs. Blue Jays prediction includes a moneyline, player prop, and a home run bet. Lock in these MLB picks before today's first pitch at 3:07 p.m. ET from Rogers Centre (Toronto), streaming exclusively on MLB.TV.
The Blue Jays are -170 betting favorites at home this afternoon, despite losing 7 of their last 10 games.
βΎ Reds vs. Blue Jays picks & odds today
See all of our expertsβ MLB picks based on the latest MLB odds;
| Pick | Best Odds | Units |
|---|---|---|
| Reds Moneyline | +150 via BetMGM | 1.00 units to win 1.50 units |
| Vladimir Guerrero Jr. Under 1.5 Hits+Runs+RBIs | +121 via DraftKings | 2.00 units to win 2.42 units |
| Elly De La Cruz Home Run | +410 via FanDuel | 0.25 units to win 1.02 units |
Total wagered: 3.25 units | Max profit: 4.94 units
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π Who will win Reds vs. Blue Jays?
The Blue Jays have struggled down the stretch, losing 4 of their previous 5 games. Williamson has pitched better on the mound for the Reds lately, limiting opposing lineups to 2 earned runs in his last 12.0 innings of work. The Reds take this series finale with a 6-3 win at Rogers Centre.
Score prediction: Reds 6, Blue Jays 3
π° Reds vs. Blue Jays prediction & best bet
Reds Moneyline (+150)
Max Scherzer has been bad for the Blue Jays in 2026. In his last 3 starts, he's allowed 14 hits, 7 walks, and 11 earned runs.
The Reds' lineup has been productive at the plate in this series so far, scoring 5+ runs in both outings. The Blue Jays have trailed after 3 innings in four straight games played.
Brandon Williamson has been much improved for the Reds, shutting out the Braves in 6.0 innings pitched during his last start on September 22nd.
Go to BetMGM and bet on the Reds moneyline at +150 odds.
📡 SBR Edge: Fade the Public
71 percent of public bets are on the Blue Jays moneyline.
π₯ Best Reds vs. Blue Jays player prop bet
Vladimir Guerrero Jr. Under 1.5 Hits+Runs+RBIs (+121)
Speaking of disappointment, Vladimir Guerrero Jr. has had arguably the worst season for any star hitter in the MLB. The Blue Jays' 1B has struggled at the plate in a major way, with only 9 home runs in 2026.
It's why Guerrero has cashed Under 1.5 Hits+Runs+RBIs in 4 of his last 5 contests. Williamson's pitching should prevent Guerrero from doing a lot of damage in this game, as the southpaw has limited 3 straight lineups to 3 or fewer hits and 2 total earned runs.
Fade Guerrero Jr. with Under 1.5 Hits+Runs+RBIs on DraftKings at +121 odds.
π£ Reds vs. Blue Jays home run prediction
Elly De La Cruz to hit a home run (+410)
Elly De La Cruz has been a bona fide slugger throughout his career and has had a strong finish to his 2026 campaign. The Reds' SS has hit 2 home runs in his previous 5 appearances.
De La Cruz is maxing out in avg exit velo at 94.7 mph (100th percentile). He's also sitting in the 98th percentile for barrel percentage (16.4) and 96th in xSLG (.507) and hard-hit rate (53.5) this season.
Scherzer's barrel rate allowed is 8.8. This puts him in the bottom 25th percentile amongst MLB pitchers.
De La Cruz is on fire, and he's got a soft matchup today. Let's bet on De La Cruz's home run prop at +410 odds on FanDuel.
π Live Reds vs. Blue Jays odds
Since lines were released for this game, the Blue Jays have moved from -175 to -181, growing a bit shorter as a home favorite. The run total has stayed flat at 8.5.
71 percent of public bets are on the Blue Jays moneyline, while 80 percent of run line wagers are on the Reds +1.5. 60 percent of total bets are on Over 8.5 from public action.
π Reds vs. Blue Jays betting trends
| Reds | Statistic | Blue Jays |
|---|---|---|
| 75-86 | W-L record | 78-83 |
| 83-78 | Run line record | 78-83 |
| 84-74-3 | O/U record | 81-75-5 |
| 5-5 | Last 10 games | 3-7 |
| 4.83 | Team ERA | 3.91 |
| .229 | Team batting avg. | .248 |
| .700 | OPS | .692 |
π Reds vs. Blue Jays injuries
πΊ How to watch Reds vs. Blue Jays
- Date: Sunday, Sept. 27
- First pitch: 3:07 p.m. ET
- Ballpark: Rogers Centre (Toronto, Ontario)
- Streaming: MLB.TV
- Reds starter: Brandon Williamson (5-4, 4.89 ERA)
- Blue Jays starter: Max Scherzer (3-9, 6.14 ERA)
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