MLB Best Home Run Predictions Today: Best HR Props, Picks, Parlay & Odds For Monday, Sept. 14

My best home run predictions today break down the best HR bets for today's MLB slate.
San Francisco Giants slugger Bryce Eldridge as we break down our MLB Best Home Run Predictions Today. Photo by Kelley L Cox-Imagn Images.
San Francisco Giants slugger Bryce Eldridge as we break down our MLB Best Home Run Predictions Today. Photo by Kelley L Cox-Imagn Images.
Enjoying SBR content? Add us as a preferred source on your Google account Add as a preferred source on Google

We're getting a solid 10-game MLB slate on Monday, with some prime matchups to assess with my home run predictions today. Lawrence Butler went deep to cash a +490 home run prop on Sunday, so let's build off that win during tonight's games. 

My latest MLB home run picks start with Kazuma Okamoto. The Blue Jays' 3B has been red-hot at the plate, recording 4 home runs in September, dwarfing the rest of Toronto's lineup with 32 homers in 2026. Okamoto faces Troy Melton on the mound for the Tigers at Rogers Centre tonight, who has allowed 3 home runs in his previous two starts.  


⚾ Home run predictions today: MLB HR picks & odds Sept. 14

See all of our experts’ MLB picks based on the latest MLB odds.

πŸ’£ Home run pick πŸ’΅ Units πŸ“ Notes
Kazuma Okamoto (+480 via DraftKings) 0.25u β†’ 1.20u Okamoto has 4 home runs in September, while logging 22 of 32 home runs against right-handed pitchers. 
Bryce Eldridge (+610 via DraftKings) 0.25u β†’ 1.52u Eldridge ranks 95th in hard-hit percentage (52.5) and 94th for avg exit velo (92.7) in 2026.
Jake McCarthy (+760 via DraftKings) 0.25u β†’ 1.90u McCarthy has hit 11 of 15 home runs against right-handed pitching, including 6 of 9 home runs at Coors Field against righties. 

Total wagered: 0.75 units | Max profit: 4.62 units

📃 Affiliate disclosure

Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)

πŸ’£ Best home run predictions & odds today

Home run pick: Kazuma Okamoto (+480)

Okamoto has been dominant against right-handed pitching in 2026, finding the bleachers on 22 of his 32 home runs in these matchups. Now, Okamoto returns to Rogers Centre, where he's logged 2 home runs in his last 3 games

The Japanese slugger ranks in the 90th percentile for barrel percentage (13.7) and sits 77th for avg exit velo (90.6) and 78th for xSLG (.451) this season. Okamoto will face right-handed starter Troy Melton, who has surrendered 3 home runs in his last two starts for the Tigers.

Go to DraftKings to bet on Okamoto's home run prop at +480 odds. 

  • Time: 7:07 p.m. ET
  • Where to watch: MLB.TV

📡 SBR Edge: Melton down

Troy Melton has allowed 4 home runs in his last two combined road starts. 

πŸ”₯ More home run predictions today

Home run pick: Bryce Eldridge (+610)

The Giants' season is virtually over, but they still have young talent in their lineup, particularly with Eldridge. He's a lefty, so an early matchup against the Cardinals' southpaw Quinn Mathews could be difficult during Eldridge's first couple of at-bats.

However, Eldridge has hit 6 of his 16 home runs against left-handed pitching, despite only logging 121 at-bats compared to 255 at-bats against righties. He's a textbook slugger, ranked in the 94th and 95th percentile for avg exit velo (92.7) and hard-hit percentage (52.5) this season.

Mathews just gave up 2 home runs in his last start against the Giants, including a 1st inning home run to Eldridge at Oracle Park. Eldridge will take Mathews deep again at Busch Stadium tonight.

Stay on DraftKings to bet on Eldridge's home run prop at +610 odds. 

  • Time: 7:45 p.m. ET
  • Where to watch: MLB.TV

Home run pick: Jake McCarthy(+760)

There's nothing like taking home run bets at Coors Field. The high altitude enhances the ability of hitters to go yard, and now we've got a prime matchup for the Rockies' lineup against Casey Mize. 

McCarthy has mashed 11 of 15 home runs against right-handed pitching in 2026. He's a lefty at the plate, recording 6 of 9 home runs at Coors Field against righties

Mize has allowed 7 home runs in his last four starts for the Padres. The last time McCarthy played at home, he found the bleachers. He's also ranked in the 87th percentile for launch angle sweet-spot percentage (38.4)

DraftKings continues to offer the best lines, so bet on McCarthy to hit a home run at +760 odds. 

  • Time: 8:40 p.m. ET
  • Where to watch: MLB.TV

πŸš€ Best home run parlay picks today

💵 Best MLB home run parlay today

  • Kazuma Okamoto (+480)
  • Bryce Eldridge (+610)
  • Jake McCarthy (+760)

Best odds: +35315 via DraftKings (0.10u -> 35.31u)