NFL Odds & Week 2 Schedule | Betting Lines, Spreads and Totals for Every Game
📊 NFL odds Week 2, 2026
The NFL odds for Week 2 are via bet365.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Lions vs. Bills (TNF) | Bills -4.5 | DET +170 / BUF -205 | 53.5 |
| Panthers vs. Falcons | Panthers -1.5 | CAR -125 / ATL +105 | 44.5 |
| Bengals vs. Texans | Texans -3 | CIN +125 / HOU -150 | 46.5 |
| Browns vs. Buccaneers | Buccaneers -8.5 | CLE +325 / TB -425 | 40.5 |
| Packers vs. Jets | Packers -3.5 | GB -210 / NYJ +175 | 44.5 |
| Vikings vs. Bears | Bears -5.5 | MIN +200 / CHI -245 | 49.5 |
| Saints vs. Ravens | Ravens -8.5 | NO +325 / BAL -425 | 47.5 |
| Eagles vs. Titans | Eagles -7 | PHI -340 / TEN +270 | 39.5 |
| Steelers vs. Patriots | Patriots -5.5 | PIT +195 / NE -240 | 41.5 |
| Jaguars vs. Broncos | Broncos -2.5 | JAX +125 / DEN -150 | 44.5 |
| Raiders vs. Chargers | Chargers -6.5 | LV +250 / LAC -310 | 43.5 |
| Dolphins vs. 49ers | 49ers -13.5 | MIA +625 / SF -950 | 45.5 |
| Seahawks vs. Cardinals | Seahawks -4.5 | SEA -225 / ARI +185 | 41.5 |
| Commanders vs. Cowboys | Cowboys -3.5 | WSH +160 / DAL -190 | 50.5 |
| Colts vs. Chiefs (SNF) | Chiefs -6.5 | IND +240 / KC -300 | 47.5 |
| Giants vs. Rams (MNF) | Rams -7.5 | NYG +280 / LAR -360 | 48.5 |
Our NFL picks will be locked and loaded for Week 2 as we get ready for the season's second week.
- The new Highmark Stadium hosts its first regular-season game when the Bills (-4.5) host the Lions on Thursday Night Football; kickoff: 8:15 p.m. ET (Prime Video)
- A loaded Sunday slate wraps with two of the AFC's top teams as the Colts visit the Chiefs (-6.5) at Arrowhead Stadium on Sunday Night Football; kickoff: 8:20 p.m. ET (NBC)
- The Rams return to North America to host the Giants at SoFi Stadium on Monday Night Football; kickoff: 8:15 p.m. ET (ESPN/ABC)
🏈 Lions vs. Bills: Thursday Night Football
- Kickoff: 8:15 p.m. ET from Highmark Stadium (Orchard Park, N.Y.)
- How to watch: Prime Video
🏈 Cowboys vs. Giants: Sunday Night Football
- Kickoff: 8:20 p.m. ET from Arrowhead Stadium (Kansas City, Mo.)
- How to watch: NBC
🏈 Broncos vs. Chiefs: Monday Night Football
- Kickoff: 8:15 p.m. ET from SoFi Stadium (Inglewood, Calif.)
- How to watch: ESPN/ABC
📈 NFL Week 2 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line with your NFL predictions. The closer you wait until kickoff to make your picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
📺 Who's playing on prime time in Week 2?
Just three prime-time games on the schedule in Week 2, the standard Thursday, Sunday, and Monday Night Football. The Detroit Lions and Buffalo Bills clash at the new Highmark Stadium in Orchard Park, N.Y., at 8:15 p.m. ET on TNF (Prime Video), a packed Sunday wraps up with the Indianapolis Colts against the Kansas City Chiefs at 8:20 p.m. ET (NBC) on SNF, and the week ends with the New York Giants at the Los Angeles Rams on MNF at 8:15 p.m. ET (ESPN/ABC).
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