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WINSTON-SALEM, NC - SEPTEMBER 24: Sam Hartman #10 of the Wake Forest Demon Deacons drops back to pass against the Clemson Tigers during the first half of their game at Truist Field on September 24, 2022 in Winston-Salem, North Carolina. Lance King/Getty Images/AFP (Photo by Lance King / GETTY IMAGES NORTH AMERICA / Getty Images via AFP)

Week 4 had some shocking results and we're anticipating more this week. Here are the best upset bets for Week 5 of the college football season.

Kansas State won at No. 6 Oklahoma, Middle Tennessee demolished No. 25 Miami, and James Madison knocked off Appalachian State in three of the biggest upsets of Week 4. There were also a few close calls, with USC and Clemson barely hanging on to remain undefeated. Who is on upset alert this weekend?

Here are our top college football upset picks and predictions for Week 5 (odds via DraftKings Sportsbook, FanDuel Sportsbook)

College Football Upset Picks for Week 5

  • Wake Forest (+215 via DraftKings Sportsbook) ★★★
  • Kansas (+132 via FanDuel Sportsbook) ★★★
  • Louisiana-Lafayette (+290 via FanDuel Sportsbook) ★★★

Week 5 College Football Upset Predictions

Wake Forest (+215) ★★★

The Wake Forest Demon Deacons could suffer a hangover after their thrilling double-overtime loss to No. 5 Clemson. The question is, how long will the hangover last?

They have to travel to Tallahassee to take on the 4-0 Florida State Seminoles for what has suddenly become a very intriguing Top 25 matchup. The Seminoles are fresh off a dominant win over Boston College and they will have the advantage of playing back-to-back games at home.

However, the reason why Wake Forest is such a good upset pick this week is because of Sam Hartman. The senior quarterback has thrown for 300-plus yards in every game this season, and he has 13 touchdowns and just two interceptions so far. The Seminoles are only allowing 165.8 yards per game through the air, but they haven’t faced a quarterback like Hartman.

Check out the latest comprehensive and most trusted Sportsbook Reviews by SBR.

Kansas (+132) ★★★

Kansas is 4-0 and the surprise of the college football season thus far. This week, the Jayhawks face Iowa State for what will be their toughest home test so far.

The Cyclones are coming off a 31-24 loss to Baylor, which was not as close as the final score suggests. They won their first three games, including a 10-7 defeat of Iowa, but looking at the schedules, the Jayhawks actually have the more impressive wins. 

The Cyclones’ defense could pose problems for the Jayhawks, who have scored 48.5 points per game. However, Jalon Daniels has done a great job of taking care of the ball for the Jayhawks this season and has thrown 11 touchdowns and one interception so far. If the Jayhawks can get out to an early lead and keep the crowd involved, then they may be able to win this one convincingly.

Louisiana-Lafayette (+290) ★★★

The Louisiana-Lafayette Ragin’ Cajuns have lost back-to-back games to Rice and Louisiana-Monroe, and they now have to take on South Alabama who is just two points away from being 4-0 on the season.

However, the Ragin’ Cajuns have owned the Jaguars in this series. They have won the last six matchups, and the Jaguars have never won a road matchup in Lafayette. Yes, the Jaguars have been impressive, averaging 38.8 points and 449.5 yards per game. They also caught everyone’s attention when they nearly defeated UCLA.

The Ragin’ Cajuns have been disappointing, but this is not a team without talent. Additionally, home-field advantage is a very big deal in college football. The Jaguars may be better, but they have had zero success in Lafayette. With a price this nice, it’s worth taking the home team to win outright.

Where to Bet on College Football Upset Picks

Here are our top-rated sportsbooks:

FanDuel Sportsbook
Caesars Sportsbook
DraftKings Sportsbook

SEE ALSO: All picksodds, and sports betting news. Be sure to check out’s community forums and betting tools.

College football upset picks made 9/26/2022 at 10:47 a.m. ET