San Jose State vs. USC Predictions: College Football Week 0 Odds & Best Bet

My San Jose State vs. USC predictions back the Trojans to make a statement on Saturday as Lincoln Riley opens his fifth season with the program.

Kickoff from Los Angeles Memorial Coliseum is set for 3 p.m. ET (NBC). My early picks like No. 14 USC as a 38.5-point betting favorite in the opening odds.

🏈 Early San Jose State vs. USC prediction: Week 0

Stay ahead with the rest of our early college football picks.

USC -38.5 (+100 via DraftKings)

This should not be even money. Yes, that is a massive number. Asking the USC Trojans to win by six possessions should not be taken lightly. But the +100 odds on it suggest this spread is going to move toward San Jose State, and that is even more foolish.

Riley and USC have gone 6-1 against the spread (ATS) in the first two weeks of the season against Group of Six competition over the last four years, including one ATS win against Stanford in 2022; the Cardinal were more a “Group of” team than an ACC team, if everyone is being honest.

San Jose State returns no defensive starters from 2025. Trojans quarterback and Heisman dark horse Jayden Maiava should be able to pick that apart.

📊 Live San Jose State vs. USC odds: Week 0

See the latest college football odds for every game in real time.

San Jose State vs. USC line movement

These lines have been available for months. They have largely been beaten into shape. But if there is any movement before the weekend, it should be toward an Over.

📺 How to watch San Jose State vs. USC

• Date: Saturday, Aug. 29
• Kickoff: 3 p.m. ET
• Location: Los Angeles Memorial Coliseum (Los Angeles)
• TV: NBC