Missouri vs. Ole Miss Prediction: Week 7 Odds, Picks & Best Bet
A top-15 tilt between SEC opponents with a big contrast in style is the central focus of my Missouri vs. Ole Miss prediction. No. 9 Ole Miss, led by QB Trinidad Chambliss, returns home to host No. 13 Missouri, which just held Texas A&M without a touchdown in a dominant Week 6 win.
Ole Miss is a -5.5-point betting favorite at Vaught-Hemingway Stadium in Oxford, Miss., leading up to Saturday's opening kickoff at 3:30 p.m. ET (SEC Network).
🏈 Missouri vs. Ole Miss picks & predictions
See all of our experts' college football picks for Week 7 based on the latest college football odds.
| Pick | Bet size |
|---|---|
| Missouri +5.5 (-110 via DraftKings) | 2.20 units to win 2.00 units |
| Under 58.5 (-105 via bet365) | 1.05 units to win 1.00 units |
Total wagered: 3.25 units | Max profit: +3.00 units
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💰 Missouri vs. Ole Miss prediction & best bet
Check out all of our college football predictions for more analysis across this week's slate.
Missouri +5.5 (-110 via DraftKings)
Missouri's defense is the biggest reason to back the Tigers on the road against a top-25 offense like Ole Miss. Under head coach Eli Drinkwitz, Missouri has held Florida and Texas A&M to 23 total points and stingy yards-per-carry averages of 1.7 and 1.2, respectively.
Chambliss is going to air it out to combat Missouri's shutdown run defense. The Tigers have recorded at least 1 interception in 4 of 6 starts, while the Ole Miss signal-caller has thrown an interception in 3 straight starts.
In this matchup, it's an elite offense against an elite defense. Let's not forget, Missouri's offense sits inside the top-40, averaging between 5.6 and 6.1 YPC against the Gators and Aggies in back-to-back outings.
Missouri's lone loss came on the road against Mississippi State. It's a business trip in their return to The Magnolia State, where the Tigers can lean exploit a porous Ole Miss defense to stay within five points.
📡 SBR Edge: Follow the Steam
Missouri has moved from +6.0 to +5.5, while it draws a matchup against an Ole Miss defense ranked 109th in points allowed per game (28.0) in 2026.
Missouri Gets Revenge in The Magnolia State
Missouri has a big advantage in this game. Ole Miss relies on its high-octane offense to put up points via explosive pass plays, while Missouri can play a methodical offense, chewing up the clock and leaning on a strong run game to put the Rebels behind schedule.
The Tigers will be able to make Ole Miss one-dimensional, forcing Chambliss into miscues with pressure and playing from behind. A big piece of Ole Miss' offense is its rushing attack. Missouri is elite at shutting down the run, which will lead to another massive win for the Tigers.
Score prediction: Missouri 31, Ole Miss 27
📊 Live Missouri vs. Ole Miss odds
Missouri vs. Ole Miss opening odds
- Moneyline: Missouri +220 | Ole Miss -275
- Spread: Missouri +6.0 (-112) | Ole Miss -6.0 (-108)
- Over/Under: Over 57.5 (-110) | Under 57.5 (-110)
📺 How to watch Missouri vs. Ole Miss: Week 7
- Date: Saturday, Oct. 17
- Kickoff: 3:30 p.m. ET
- Location: Vaught-Hemingway Stadium (Oxford, Miss.)
- TV: SEC Network
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Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)
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