Oklahoma State vs. Houston Prediction: Week 7 Odds, Picks & Best Bet
Drew Mestemaker leads the hottest team in the Big 12 back on the road for a top-20 matchup Saturday as I make my Oklahoma State vs. Houston prediction.
No. 18 Oklahoma State is 4-0 since upsetting Oregon in Week 2, while No. 20 Houston is riding a three-game winning streak. Houston is a 4.5-point betting favorite, with kickoff from TDECU Stadium in Houston set for 7:30 p.m. ET (FOX).
Oklahoma State vs. Houston picks & predictions
See all of our experts' college football picks for Week 7 based on the latest college football odds.
| Pick | Bet size |
|---|---|
| Oklahoma State +4.5 (-109 via bet365) | 4.36 units to win 4 units |
| Under 63.5 (-115 via FanDuel) | 1.15 units to win 1 unit |
Total wagered: 5.51 units | Max profit: +5 units
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Oklahoma State vs. Houston prediction & best bet
Check out all of our college football predictions for more analysis across this week's slate.
Oklahoma State +4.5 (-109 via bet365)
This Oklahoma State offense is no joke. Mestemaker has led the Cowboys on a tear since beating the Ducks, scoring 39+ points in four straight wins while logging over 300 passing yards in each outing during this hot streak.
Houston's defense has been solid, limiting opponents to 28 or fewer points in every game played. It's why the Cougars are a top-40 scoring defense (19.2) this season.
Houston QB Connor Weigman's dual-threat ability could be tested against an Oklahoma State run defense that has held all but one team, West Virginia, to 3.3 YPC or fewer during its current winning streak. Mestemaker is undoubtedly the best signal-caller in this game.
We're getting +4.5 on Oklahoma State, moving up from +3.5. We're through a key number here and Houston's offense, despite entering as a top-20 unit, won't match Mestemaker's arm talent.
Go to bet365 and bet Oklahoma State +4.5 at -109 odds.
📡 SBR Edge: Cowboys Cover as Dogs
Oklahoma State has covered the spread in six straight games as an underdog.
Mestemaker's arm keeps Cowboys undefeated in Big 12
Houston's lone loss came against a Texas Tech offense that logged 5.3 YPC. The Cowboys' ground game is solid, averaging 5.1 YPC this season, but its passing attack is going to be the biggest challenge the Cougars have faced so far.
Mestemaker is a stud. He's thrown for 300+ yards in every win, including 10 touchdowns and one interception in his previous three combined starts. Mestemaker's arm will continue to dice coverage, keeping Oklahoma State undefeated in conference play with an upset win on the road against Houston.
Score prediction: Oklahoma State 34, Houston 27
Live Oklahoma State vs. Houston odds
Oklahoma State vs. Houston opening odds
- Moneyline: Oklahoma State +136 | Houston -162
- Spread: Oklahoma State +3.5 (-108) | Houston -3.5 (-112)
- Over/Under: Over 57.5 (-115) | Under 57.5 (-105)
How to watch Oklahoma State vs. Houston: Week 7
- Date: Saturday, Oct. 17
- Kickoff: 7:30 p.m. ET
- Location: TDECU Stadium (Houston)
- TV: FOX
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