LSU vs. Ole Miss Prediction: Week 3 Odds, Picks & Best Bet
Vaught-Hemingway Stadium in Oxford will be rocking for Lane Kiffin’s return in this top-10 showdown between No. 7 LSU and No. 8 Ole Miss, and that homefield advantage is why I’m backing the Rebels with my LSU vs. Ole Miss prediction.
Much like the Ole Miss coaching staff, I’m not buying that LSU quarterback Sam Leavitt is hurt enough to be doubtful to play on Saturday. While that news did move the line somewhat, I’m comfortable with the number that the home underdogs are getting.
Kickoff is set for 7:30 p.m. ET airing on ABC, and LSU is a 2.5-point betting favorite.
🏈 LSU vs. Ole Miss picks & predictions
See all of our experts' college football picks for Week 3 based on the latest college football odds.
| Pick | Bet size |
|---|---|
| ATS: Ole Miss +2.5 (-108 via DraftKings) | 1 unit to win 0.93 units |
| O/U: Under 57.5 (-110 via bet365) | 1 unit to win 0.91 units |
Total wagered: 2 units | Max profit: 1.84 units
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💰 LSU vs. Ole Miss prediction & best bet
Check out all of our college football predictions for more analysis across this week's slate.
🦈 Ole Miss +2.5 (-108 via DraftKings)
The lookahead line for this game over the summer was Ole Miss -2.5, and has since jumped the fence after LSU won its first two games by an average of 36 points. But the Rebels are the team that have a win over a ranked Louisville squad so far, and it’s likely that the Tigers’ blowout win over Clemson won’t look as impressive by the end of the season.
Lane Kiffin’s teams historically have been horrible in this spot. He is 1-8 as a head coach in road games against AP top 10 teams, with the lone win coming as coach of No. 18 USC over No. 4 Oregon in 2011.
The home team has won the last six meetings in this rivalry, and I wouldn’t put anyone off backing the Ole Miss moneyline (+115 is the best price at bet365), even though I’m comfortable taking the points as my best bet.
📡 SBR Edge: Pulling out the close ones
Ole Miss quarterback Trinidad Chambliss is 5-1 in one-score games over the last two seasons, the second-highest winning percentage in the SEC.
LSU's defense will finally get challenged
From its performances in wins over Clemson and Louisiana Tech, LSU leads the country in total defense and in sacks, while allowing just 18 rushing yards per game. It also ranks first in pressure percentage (52.5%) tied for eighth in forced fumbles (three) and tied for 30th in interceptions (two). As such, LSU is the only FBS team with 10 sacks, three forced fumbles, and two interceptions.
But the Tigers haven’t faced a quarterback in the same stratosphere talent-wise as Trinidad Chambliss. He has a leg up over his counterpart, Sam Leavitt, as Chambliss has an 87 career Total QBR with five turnovers, while Leavitt has logged a 75 career Total QBR with 18 turnovers.
In 10 home games since 2025, Ole Miss has forced eight interceptions and recorded 18 sacks. The home environment should again be the difference with Chambliss keeping the offense on schedule with his elite 80% completion percentage on first and second down.
Score prediction: Ole Miss 28, LSU 27
📊 Live LSU vs. Ole Miss odds
See the latest college football odds for every Week 3 matchup.
LSU vs. Ole Miss opening odds
- Moneyline: LSU -140 | Ole Miss +115
- Spread: LSU +2.5 (-110) | Ole Miss -2.5 (-110)
- Over/Under: Over 57.5 (-110) | Under 57.5 (-110)
📺 How to watch LSU vs. Ole Miss: Week 3
- Date: Saturday, Sept. 19
- Kickoff: 7:30 p.m. ET
- Location: Vaught-Hemingway Stadium (Oxford, Miss.)
- TV: ABC
- Streaming: WatchESPN
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