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Malik Nabers of the LSU Tigers reacts after an LSU victory at Jordan-Hare Stadium on October 1, 2022 in Auburn, Alabama.
Malik Nabers of the LSU Tigers reacts after an LSU victory at Jordan-Hare Stadium on October 1, 2022 in Auburn, Alabama. Photo by Brandon Sumrall/Getty Images via AFP.

Breaking down the opening odds and attempting to predict how the lines will move for some of the biggest matchups on the Week 6 college football schedule.

Another weekend of college football is in the books. Week 5 provided several thrilling finishes. numerous upsets, and a few VERY close calls. Yeah, we’re looking at you, Georgia. 

The action only figures to get more intense from here as the College Football Playoff race heats up. As we close in on the halfway point of the season, even teams who are not in the CFP mix still have the motivation to reach six wins in order to make a bowl game.

When it comes to our list of college football games to watch in Week 6, the noon window on Saturday really stands out. Multiple ranked matchups and a major rivalry game at the Texas State Fair headline the action. Throw in massive games in both the Pac-12 and SEC scheduled for later in the day and it promises to be another entertaining weekend of football!

Here are previews and analyses for our top seven games to watch in Week 6 of the 2022 college football season (odds via DraftKings Sportsbook).

Top College Football Matchups to Watch in Week 6

Arkansas vs. (23) Mississippi State

Date: Saturday, Oct. 8, noon ET
TV: SEC Network
Location: Davis-Wade Stadium, Starkville, MS
Odds: MSU -5 | O/U 62

Aside from the third quarter, Arkansas was thoroughly outclassed in last week’s home game against Alabama. The Razorbacks will look to snap their two-game losing skid when they head to Starkville to face a newly-ranked Mississippi State team.

After the Bulldogs throttled Texas A&M in Week 5, it was no surprise to see oddsmakers open them as 6-point favorites. While DraftKings sits a full point lower at the time of writing, one would have to believe that the line will shift in Mississippi State’s favor. Head coach Mike Leach’s experienced roster may not be flying under the radar much longer.

(8) Tennessee vs. (25) LSU

Date: Saturday, Oct. 8, noon ET
TV: ESPN
Location: Tiger Stadium, Baton Rouge, LA
Odds: TENN -4 | O/U 62

Another massive SEC battle scheduled for Saturday’s noon window is a matchup between Tennessee and LSU. The Volunteers sat idle this past week while the Tigers escaped with a hard-fought road win over Auburn.

With Tennessee opening up as a 4-point road favorite, it will be fascinating to see how the line moves in the lead-up to game day. Bettors will also need to keep tabs on the status of LSU quarterback Jayden Daniels, who got knocked out of last week’s contest with a knee injury.

(17) TCU vs. (19) Kansas

Date: Saturday, Oct. 8, noon ET
TV: FS1
Location: David Booth Kansas Memorial Stadium, Lawrence, KS
Odds: TCU -6.5 | O/U 67.5

After being picked to finish last in the preseason Big 12 media poll, Kansas enters Week 6 undefeated and ranked 19th in the AP Poll. Joining the Jayhawks as a newcomer in the Top 25 this week is a TCU team that is riding high after a thorough beatdown of Oklahoma.

Only one of these teams can walk out of Saturday’s showdown with their perfect record intact. Oddsmakers seem to believe it will be the Horned Frogs that do so. After opening as a 5-point road favorite, TCU is now laying six or more across the market. Given the Jayhawks’ feel-good story, KU could very well wind up being a public underdog.

Texas vs. Oklahoma

Date: Saturday, Oct. 8, noon ET
TV: ABC
Location: Cotton Bowl, Dallas, TX
Odds: TEX -6.5 | O/U 65

Notably absent from the 118th edition of the Red River Showdown is a ranked participant. Saturday’s matchup between Texas and Oklahoma marks the first time since 1998 that neither team is ranked in the AP Poll coming into the game.

With the Sooners having suffered two ugly losses in a row, it’s no surprise to find the betting market leaning towards Texas early on. The Longhorns opened as 5-point favorites and are now laying nearly a full touchdown. OU has notably won six of the last seven meetings, including the 2018 Big 12 title game.

Check out the latest comprehensive and most trusted Sportsbook Reviews by SBR.  

Georgia Southern vs. Georgia State

Date: Saturday, Oct. 8, 2 p.m. ET
TV: ESPN3
Location: Carter Parc Stadium, Atlanta, GA
Odds: GSU -2.5 | O/U 65.5

When it comes to mid-major games to watch this weekend, the Sun Belt Conference rivalry between Georgia Southern and Georgia State stands out. Those who are in tune with college football’s biggest rivalries have to appreciate this game’s nickname of “Modern Day Hate”.

After earning their first win of the season, the Panthers opened as 3-point home favorites. The Eagles lost a heartbreaker to Coastal Carolina last week and have exceeded expectations through five weeks of play. Georgia State began the year with a much higher power rating, so it will be interesting to see how the market's view of these teams has adjusted.

(11) Utah vs. (18) UCLA

Date: Saturday, Oct. 8, 3:30 p.m. ET
TV: FOX
Location: Rose Bowl, Pasadena, CA
Odds: UTA -3 | O/U 64

For the second week in a row, the Rose Bowl is the site for one of our college football games to watch. UCLA entered the AP Top 25 after cruising past Washington. An even tougher test awaits in Week 6 when the defending Pac-12 champs come to town.

Saturday’s trip to Pasadena will easily be the toughest game Utah has had since a season-opening loss at Florida. Interestingly enough, oddsmakers opened the spread at the same 3-point margin that the Utes were favored by in Gainesville. If this line moves at all, it will probably be in Utah’s favor.

Texas A&M vs. (1) Alabama

Date: Saturday, Oct. 8, 8 p.m. ET
TV: CBS
Location: Bryant-Denny Stadium, Tuscaloosa, AL
Odds: ALA -24 | O/U 52

Coming into the 2022 college football season, the showdown between Texas A&M and Alabama was considered to be one of the marquee games of the year. While the stakes are plenty high, the Aggies’ shaky start has certainly deprived this matchup of some of its luster.

Before the season began, it’s hard to imagine many betting analysts would’ve expected the Crimson Tide to be favored so heavily in this spot. Alabama opened as a 20-point home favorite. The spread ballooned to ‘Bama -24 in a matter of hours. Given how anemic the A&M offense has been, the Tide may not even need QB Bryce Young to win decisively.

Where To Bet on College Football

Here are our top-rated sportsbooks:

FanDuel Sportsbook
Caesars Sportsbook
DraftKings Sportsbook
PointsBet
BetMGM

SEE ALSO: All picks, odds, and sports betting news. Be sure to check out SportsbookReview.com’s community forums and betting tools.