College Football Moneyline Picks Week 2: Predictions to Win This Week

Our college football moneyline picks for Week 2 predict the outright winner of 16 key matchups, plus analysis of our three favorite moneyline bets.
Oklahoma Sooners QB John Mateer in action as we break down our college football Week 2 moneyline picks. Photo by Kevin Jairaj-Imagn Images.
Oklahoma Sooners QB John Mateer in action as we break down our college football Week 2 moneyline picks. Photo by Kevin Jairaj-Imagn Images.
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I'm highlighting 17 Week 2 games below as I make my best college football moneyline picks. The most exciting matchup on the schedule is No. 1 Ohio State vs. No. 5 Texas. I explain why I expect Ohio State to pull off the upset and remain No. 1 in the nation.

I also have my eye on No. 10 Oklahoma visiting No. 16 Michigan. Are the Wolverines being overvalued as just 5.5-point underdogs? Continue reading, as I pick two top-25 teams to lose to unranked opponents, then highlight one nearly double-digit underdog that I expect to win outright.


🏈 College football moneyline picks: Week 2

See all of our experts' college football picks for Week 2 based on the latest college football odds.

Matchup Pick Best odds
No. 1 Ohio State vs. No. 5 Texas No. 1 Ohio State -102 via FanDuel
Arizona State vs. No. 8 Texas A&M Texas A&M -625 via BetMGM
No. 10 Oklahoma vs. No. 16 Michigan No. 10 Oklahoma -218 via DraftKings
No. 25 Missouri vs. Kansas Kansas +190 via bet365
Rutgers vs. Boston College Boston College -170 via bet365
UCF vs. Pitt Pitt -278 via DraftKings
Florida A&M vs. No. 7 Miami No. 7 Miami -100000 via FanDuel
No. 13 Alabama vs. Kentucky No. 13 Alabama -385 via FanDuel
Mississippi State vs. Minnesota Mississippi State -108 via FanDuel
No. 2 Oregon vs. Oklahoma State No. 2 Oregon -2000 via BetMGM
Rice vs. No. 4 Notre Dame No. 4 Notre Dame N/A
Arizona vs. No. 14 BYU Arizona +240 via BetMGM
Arkansas vs. No. 21 Utah No. 21 Utah -526 via BetMGM
No. 20 Tennessee vs. Georgia Tech No. 20 Tennessee -500 via BetMGM
Iowa State vs. No. 22 Iowa No. 22 Iowa -625 via BetMGM
No. 12 Texas Tech vs. Oregon State No. 12 Texas Tech -3030 via BetMGM

🔥 Best college football moneyline picks: Week 2

No. 10 Oklahoma (-218 via DraftKings) vs. No. 16 Michigan

Bryce Underwood and the Michigan offense managed just 276 yards in Week 1, 47 of which came on the controversial game-winning Hail Mary. They also turned the ball over three times against a Western Michigan team that got outscored 61-6 by power conference teams last year.

Oklahoma steamrolled UTEP in Week 1, outgaining the Miners 401-198. Quarterback John Mateer threw for 225 yards and three touchdowns, despite playing only three quarters.

Based on Week 1 performances, I expected this spread to be greater than a touchdown, but oddsmakers seem reluctant to push the spread too far. That means a very favorable moneyline price, which is great for us.

📡 SBR EDGE

Mateer faced Michigan last season. He threw for 270 yards and a touchdown, while adding 74 rushing yards and two rushing touchdowns. Oklahoma won that game 24-13.


No. 1 Ohio State (-102 via FanDuel) vs. No. 5 Texas

With Texas at home coming off a 52-point win, I'm not surprised that the spread has moved from a pick 'em to Texas -1.5. However, I'm worried about the Texas rush defense. The Longhorns allowed Texas State to rush for 161 yards and average 3.9 yards per carry in Week 1.

While all attention is on Julian Sayin and Arch Manning, I believe Bo Jackson will be the difference in this game. Last season, he averaged 6.1 yards per carry and at least 4.9 yards per attempt against both Indiana and Miami. 

FanDuel is offering the best price for Ohio State, while some sportsbooks have the price set as high as -115.


New Mexico State (+300 via DraftKings) vs. Hawaii

For my final pick, I'm backing New Mexico State to win outright, despite being 9.5-point underdogs. New Mexico State went toe-to-toe with Florida State for the majority of its Week 0 contest, with Trey Hedden throwing for 272 yards and two touchdowns

Additionally, Hawaii is allowing 203 rushing yards per game. Now the Rainbow Warriors need to slow down an offense that ran for 235 yards last week. Granted, New Mexico State's performance came against Mercer, but it still showed that this offense is capable of a well-balanced attack led by Hedden and running back James Jones.

Hawaii has also struggled offensively, managing just 4.10 yards per play. That ranks 121st in the nation.


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