Colorado vs. Oklahoma State Prediction: Week 8 Odds, Picks & Best Bet (Oct. 24)
A prime-time Big 12 showdown, led by one of the country's top quarterbacks, is featured in my Colorado vs. Oklahoma State prediction.
Oklahoma State QB Drew Mestemaker has thrown for nearly 2,000 yards through 6 games. Oddsmakers have the Cowboys as -13.5-point betting favorites at home from Boone Pickens Stadium in Stillwater, Okla., with Saturday's kickoff at 7:00 p.m. ET (FS1).
Colorado vs. Oklahoma State picks & predictions
See all of our experts' college football picks for Week 8 based on the latest college football odds.
| Pick | Odds | Bet size |
|---|---|---|
| Oklahoma State -13.5 | (-110 via BetMGM) | 2.20 to profit 2.00 units |
| Under 56.5 | (-112 via DraftKings) | 1.12 units to profit 1.00 unit |
Picks submitted: Oct. 23 at 11:45 a.m. ET. Odds subject to change.
Total wagered: 3.32 units | Max profit: +3.00 units
📃 Affiliate disclosure
Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)
Colorado vs. Oklahoma State prediction & best bet
Check out all of our college football predictions for more analysis across this week's slate.
Oklahoma State -13.5 (-110 via BetMGM)
I'm on the public's side in the point spread betting market in this game. Mestemaker has been on a tear, leading Oklahoma State to the nation's 21st-ranked offense in 2026.
Colorado has played better defensively compared to last year. However, the Buffaloes are going to find it difficult to keep pace with the Cowboys, who average 37.2 points per game.
Oklahoma State's 35-32 loss to No. 14 Houston was the first time they've been held under 39 points since Week 1. Expect a big bounce-back from Mestemaker against a Colorado team dealing with several key injuries. Plus, the Buffaloes have only scored over 20 points once against an FBS opponent this year, finishing with 24 against No. 10 Utah in Week 7.
Bet on Oklahoma State -13.5 at -110 odds on BetMGM.
📡 SBR Edge: Poke Covers
Oklahoma State has covered the spread in 7 straight games against Big 12 opponents.
Mestemaker Picks Apart Colorado Defense in Stillwater
Colorado's offense has been anemic in 2026. The Buffaloes had their best performance of the season against undefeated Utah in their last outing. However, Oklahoma State's offense is ready for a bounce-back performance after snapping a 4-game win streak in a narrow road loss to Houston.
The Buffaloes are going to be a punching bag on both sides of the line of scrimmage. Mestemaker likely throws for 300+ and 3 touchdowns, while the Cowboys' defense has a chance to improve its play against the nation's 124th-ranked offense.
Play to: Oklahoma State -20.5
Score prediction: Oklahoma State 38, Colorado 17
Live Colorado vs. Oklahoma State odds
See the latest odds movement and more on our Colorado vs. Oklahoma State matchup page.
Colorado vs. Oklahoma State opening odds
- Moneyline: Colorado +430 | Oklahoma State -600
- Spread: Colorado +14.5 (-115) | Oklahoma State -14.5 (-105)
- Over/Under: Over 55.5 (-110) | Under 55.5 (-110)
Colorado vs. Oklahoma State weather
Boone Pickens Stadium is expected to have a 75-degree temperature at kickoff. 8 mph winds and a 0% probability of precipitation create ideal, clean conditions.
Latest Colorado vs. Oklahoma State injuries
Colorado:
- Micah Welch, RB - Questionable
- Danny Scudero, WR - Questionable
- Makari Vickers, CB - Questionable
Oklahoma State:
- None
How to watch Colorado vs. Oklahoma State: Week 8
- Date: Saturday, Oct. 24
- Kickoff: 7:00 p.m. ET
- Location: Boone Pickens Stadium (Stillwater, Okla.)
- TV/Streaming: FS1
Related Articles
