AC Milan vs. Benfica Prediction, Picks & Odds for Wednesday's Europa League Match
Last Updated: September 16, 2026 3:16 PM EDT • 3 minute read X Social Google News Link
Europa League Matchweek 1 gets underway Wednesday, and I’m targeting three wagers in my AC Milan vs. Benfica prediction.
These two European heavyweights are more accustomed to Champions League football, but both should have legitimate ambitions of making a deep run in the Europa League. AC Milan enters as the betting favorite at San Siro, with kickoff scheduled for 3 p.m. ET on Paramount+.
I expect Milan to come away with all three points, but the Over is my best bet for this Matchweek 1 clash.
⚽ AC Milan vs. Benfica predictions & best bets
See our experts' soccer picks.
| Best bets | Best odds | Wager (units) |
|---|---|---|
| Over 2.5 goals | -140 via BetMGM | 1 unit to profit 0.71 |
| AC Milan ML | +110 via FanDuel | 0.5 units to profit 0.69 units |
| Vangelis Pavlidis anytime goal scorer | +185 via FanDuel | 0.5 units to profit 0.93 units |
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💰 AC Milan vs. Benfica best bet
Check out all of our soccer betting analysis and expert predictions this season.
Over 2.5 goals (-140)
AC Milan are in the infancy of their Serie A campaign and have allowed at least one goal in three of four games under new coach Ruben Amorim’s watchful eye.
But they have enjoyed a healthy offensive start, bagging at least two goals three times. The only exception came in a 1-1 draw in Turin against a solid Juventus side. Amorim will be wary of playing a Benfica side that has been prolific going forward.
Benfica leads all teams in the Primeira Liga with 21 goals in six matches, six more than the second-most prolific teams, FC Porto and Sporting Lisbon. I like AC Milan to secure all three points, but I expect Benfica to get on the scoresheet.
🆚 Who will win AC Milan vs. Benfica?
We have what I think we will be a tight game playing out, but I do think AC Milan has what it takes to get the job done an San Siro. As I explained above, I have faith both squads will get on the sheet.
Score prediction: AC Milan 2, Benfica 1
🔥 More AC Milan vs. Benfica expert picks
Vangelis Pavlidis anytime goal scorer (+185)
Vangelis Pavlidis is not only one of the best names in world football, but he’s also hitting the back of the net more than anyone else in the Primeira Liga.
Falling to score only once, the 27-year-old has eight goals in six domestic matches.
The Benfica frontman scored one goal in three matches, along with a brace and a hat trick in the other two. His soaring confidence has compelled me to back him to score at the San Siro in a losing cause.
⚖️ AC Milan vs. Benfica key stats
| Statistic | AC Milan | Benfica |
|---|---|---|
| Record (domestic) | 2-2-0 (Serie A) | 2-1-1 (Primeira Liga) |
| Recent form (all comps) | WWDD | WWWWW |
| Goals for (domestic) | 7 | 21 |
| xG (domestic) | 5.8 | 16 |
| Goals against (domestic) | 4 | 4 |
| xGA (domestic) | 5.9 | 3.7 |
| Possession (domestic) | 58.3% | 65% |
📊 AC Milan vs. Benfica odds
🆚 AC Milan vs. Benfica projected lineups
Here are the projected lineups for AC Milan vs. Benfica; subject to change:
| AC Milan (3-4-2-1) | Benfica (4-2-3-1) |
|---|---|
| Maignan (GK) | Soares (GK) |
| De Winter (D) | Aursnes (D) |
| Gabbia (D) | Araujo (D) |
| Pavlovic (D) | Lenglet (D) |
| Chukwueze (D) | Dahl (M) |
| Modric (M) | Palhinha (M) |
| Musah (M) | Barreiro (M) |
| Moreira (M) | Silva (M) |
| Pulisic (M) | Prestianni (M) |
| Cisse (M/F) | Schjelderup (F) |
| Ramos (F) | Pavlidis (F) |
📺 How to watch AC Milan vs. Benfica
- Date: Wednesday, Sept. 16
- Kickoff: 3 p.m. ET
- Location: San Siro (Milan)
- TV/Streaming: Paramount+
Gary Pearson X social