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Saints vs. Giants Prediction: Week 6 Odds, Picks & Best Bet

Our Saints vs. Giants prediction for Week 6 includes our best bet, projected score, and the latest odds for Sunday's matchup.

Liam Fox

Last Updated: October 17, 2026 12:30 PM EDT • 2 minute read

Pictured: New York Giants linebacker Arvell Reese (52) celebrates after blocking a pass as we offer our Saints vs. Giants prediction. Photo by USA TODAY Network via Reuters Connect.

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New York looks to hold on to first place in the NFC East as I provide my Saints vs. Giants prediction for Sunday's matchup.

Kickoff from MetLife Stadium in East Rutherford, N.J., is set for 1 p.m. ET (FOX), with the Saints priced as a 1.5-point betting favorite.

Saints vs. Giants picks & predictions

See all of our experts' NFL picks for Week 6 based on the latest NFL odds.

Pick	Bet size
Giants ML (-104 via FanDuel)	1 unit
Over 45.5 (-110 via FanDuel)	0.5 units

Total wagered: 1.5 units | Max profit: +1.42 units

Saints vs. Giants prediction & best bet

Giants ML (-104 via FanDuel)

The Giants are playing like an organized outfit under John Harbaugh - something we haven't seen out of New York in years.

A much-invested-in New York defensive line is finally rounding into shape, even without Brian Burns. The Giants have the fifth-highest pass-rush win rate, while the Saints rank 26th in pass-block win rate. So while their traditional pass-rush stats aren't great, I expect that unit to be in Tyler Shough's grill consistently and be the difference in a New York home win.

With the Giants priced as only a 1.5-point underdog, it makes more sense to back New York's moneyline to win outright. FanDuel offers the best price there at -104.

📡 SBR Edge

The Saints are tied for the worst turnover differential in the NFL at minus-6.

Saints flatlining after promising start

The Saints continue to receive the benefit of the doubt from oddsmakers after some impressive early-season flashes. But they shouldn't be a road favorite here given what we've seen from New Orleans over the last few weeks.

Forget winning: The Saints haven't kept the final score within a touchdown since Week 2. They need to show more before I throw any money their way. I'm backing the more mentally tough team in this matchup.

Score prediction: Giants 25, Saints 23

Saints vs. Giants odds

Saints vs. Giants opening odds

Moneyline: Saints -120 | Giants +100
Spread: Saints -1.5 (+100) | Giants +1.5 (-120)
Over/Under: Over 45.5 (-110) | Under 45.5 (-110)

How to watch Saints vs. Giants: Week 6

Date: Sunday, Oct. 18
Kickoff: 1 p.m. ET
Location: MetLife Stadium (East Rutherford, N.J.)
TV: FOX

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Written by:
Liam Fox

Liam Fox is a Publishing Editor for Sportsbook Review. Liam spent the past seven-plus years in the sports media industry building his NFL experience and contributing at some of North America's top outlets. His work has appeared on Sportsnet, Forbes, and Complex. He was previously an editor for nearly four years at theScore, specializing in NFL coverage. His career highlights include asking Patrick Mahomes a question at Super Bowl LV media day and shedding light on the champion Philadelphia Eagles' use of analytics through an in-depth interview with their lead data analyst. A graduate of Carleton University's Bachelor of Journalism program, you can usually find Liam writing about sports, watching sports, or playing sports.