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Cardinals vs. Rams Prediction: Week 6 Odds, Picks & Best Bet

Our Cardinals vs. Rams prediction for Week 6 includes our best bet, projected score, and the latest odds for Sunday's matchup.

Liam Fox

Last Updated: October 17, 2026 2:00 PM EDT • 2 minute read

Pictured: Los Angeles Rams quarterback Matthew Stafford (9) looks to pass as we provide our Cardinals vs. Rams prediction. Photo by Jayne Kamin-Oncea via Imagn Images.

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Los Angeles hopes to put another disappointing prime-time performance behind it Sunday as I break down my Cardinals vs. Rams prediction for Week 6.

Kickoff from SoFi Stadium in Inglewood, Calif., is set for 4:05 p.m. ET (FOX). The Rams are by far the biggest favorite of the week, priced at 12.5 to 13.5 points.

Cardinals vs. Rams picks & predictions

See all of our experts' NFL picks for Week 6 based on the latest NFL odds.

Pick	Bet size
Rams -12.5 (-118 via BetMGM)	1 unit
Under 52 (-110 via BetMGM)	0.5 units

Total wagered: 1.5 units | Max profit: +1.31 units

Cardinals vs. Rams prediction & best bet

Rams -12.5 (-118 via BetMGM)

The Cardinals were ill-equipped to hang with the Lions for all four quarters last week, losing by 24 points. The same will be true this week against a Rams squad that ranks top 10 in both offensive and defensive EPA/play.

Arizona has the league's worst scoring defense and has allowed over 400 yards of offense in two of the last three weeks. That is partly due to the Cardinals' brutal early schedule, but they simply don't have the playmakers on either side of the ball to keep pace with elite teams.

I love backing the Rams to cover the spread here below the key number of 13. BetMGM offers a solid -118 price tag on L.A. to cover 12.5.

📡 SBR Edge

The Rams are 7-3 against the spread in their last 10 games against the Cardinals.

Rams' secondary built to protect the lead

While the Rams are working through some defensive front issues without the injured Myles Garrett, their improved secondary is balling out.

Los Angeles is allowing the second-fewest passing yards per game, meaning the Cardinals won't be able to throw their way back into this contest once the Rams build a lead.

Score prediction: Rams 31, Cardinals 16

Cardinals vs. Rams odds

Cardinals vs. Rams opening odds

Moneyline: Cardinals +457 | Rams -667
Spread: Cardinals +13.5 (-110) | Rams -13.5 (-110)
Over/Under: Over 52 (-110) | Under 52 (-110)

How to watch Cardinals vs. Rams: Week 6

Date: Sunday, Oct. 18
Kickoff: 4:05 p.m. ET
Location: SoFi Stadium (Inglewood, Calif.)
TV: FOX

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Written by:
Liam Fox

Liam Fox is a Publishing Editor for Sportsbook Review. Liam spent the past seven-plus years in the sports media industry building his NFL experience and contributing at some of North America's top outlets. His work has appeared on Sportsnet, Forbes, and Complex. He was previously an editor for nearly four years at theScore, specializing in NFL coverage. His career highlights include asking Patrick Mahomes a question at Super Bowl LV media day and shedding light on the champion Philadelphia Eagles' use of analytics through an in-depth interview with their lead data analyst. A graduate of Carleton University's Bachelor of Journalism program, you can usually find Liam writing about sports, watching sports, or playing sports.