Giants vs. Rams Expert Picks for MNF: Monday Night Football Predictions (Sept. 21)
We're looking at our Giants vs. Rams expert picks ahead of Monday Night Football in Week 2. The Giants opened their season with a shocking win, looking as good as they have in years. The Rams opened their season with a disaster class in Australia, looking as poor as they have in years.
Tonight's kickoff from SoFi Stadium in Inglewood, Calif., at 8:15 p.m. ET (ABC/ESPN) might be a very different result according to our experts.
🏈 Giants vs. Rams expert picks: Monday Night Football
See all of our experts' NFL picks based on the latest NFL odds.
| Expert | Pick |
|---|---|
| Gary Pearson | Giants +7.5 |
| Philip Wood | Davante Adams anytime touchdown scorer |
| Brenden Schaeffer | Jaxson Dart Under 214.5 passing yards |
| Andrew Reid | Under 47.5 |
Gary Pearson's pick: Giants +7.5
Their secondary, meant to be one of the team’s weaknesses, held CeeDee Lamb and George Pickens to 72 combined yards, and the Jaxson Dart-led offense racked up 394 yards.
The Rams return from Australia as the only team not to score 10 points in Week 1. Myles Garrett is out, and Puka Nacua is questionable after sustaining a hip injury. Aaron Donald is making his long-anticipated return, but I expect it to take some time for the recent retiree to regain game sharpness.
See Gary Pearson's full analysis in his Giants vs. Rams prediction.
Philip Wood's pick: Davante Adams anytime touchdown scorer
Adams and Nacua accounted for 24 of Matthew Stafford's 46 touchdown passes last season. I expect Stafford to bounce back after throwing a touchdown in every regular-season game last year, and with Nacua likely out or limited, Adams should see the lion's share of red-zone targets.
See Philip Wood's full analysis in his Giants vs. Rams touchdown scorer predictions.
Brenden Schaeffer's pick: Jaxson Dart Under 214.5 passing yards
New York’s win over the Cowboys last week has people excited, but that Dallas pass defense ranked 32nd in the NFL in 2025 - of course Jaxson Dart was going to look good.
Dart only cleared this passing line of 214.5 yards four times last season. Trent McDuffie should be able to help contain the talented Malik Nabers to keep Dart’s overall passing numbers in check.
See Brenden Schaeffer's full analysis in his Giants vs. Rams same-game parlay.
Andrew Reid's pick: Under 47.5
I'm expecting this one to play out slowly as we should see a heavy dose of the clock-churning run game out of both squads.
New York toted the ball 37 times in its opener, and a similar number isn't beyond the pale tonight. The thing is, it won't see the same success against a Los Angeles team that should be looking to buckle things up after a disastrous start to the season. Similarly, I expect the Rams to look to control the clock and keep the ball out of the Giants' hands. Both these offenses can definitely put points on the board, but neither is going to make a big splash tonight.
🤑 Giants vs. Rams betting splits
Betting insights via BetMGM.
| Team / bet type | Odds | Bet % | Handle % |
|---|---|---|---|
| Giants | |||
| 🔴 Moneyline | +240 | 58% | 39% |
| 🔴 Spread | +6.5 | 51% | 30% |
| 🔴 Total | o47.5 | 54% | 59% |
| Rams | |||
| 🟡 Moneyline | -300 | 42% | 61% |
| 🟡 Spread | -6.5 | 49% | 70% |
| 🟡 Total | u47.5 | 46% | 41% |
📺 How to watch Giants vs. Rams: Monday Night Football
- Date: Monday, Sept. 21
- Kickoff: 8:15 p.m. ET
- Location: SoFi Stadium (Inglewood, Calif.)
- TV: ABC/ESPN
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