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Eagles vs. Jaguars Prediction: Week 5 Odds, Picks & Best Bet

Our Eagles vs. Jaguars prediction for Week 5 includes our best bet, projected score, and the latest odds for Sunday's matchup.

Liam Fox

Last Updated: October 10, 2026 12:00 PM EDT • 2 minute read

Pictured: Trevor Lawrence in action as we break down our Eagles vs. Jaguars Prediction. Photo by John Mersits/Cal Sport Media/Sipa USA.

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A reeling Eagles squad travels across the pond to take on the tenacious Jaguars as I break down my Eagles vs. Jaguars prediction.

Kickoff is at 9:30 a.m. ET from Tottenham Hotspur Stadium in London on Sunday (NFL Network), with the Jaguars priced as a 7.5-point neutral-site betting favorite.

Eagles vs. Jaguars picks & predictions

See all of our experts' NFL picks for Week 5 based on the latest NFL odds.

Pick	Bet size
Jaguars -7.5 (-105 via BetMGM)	1 unit
Under 42.5 (-115 via FanDuel)	0.5 units

Total wagered: 1.5 units | Max profit: +1.39 units

Eagles vs. Jaguars prediction & best bet

Jaguars -7.5 (-105 via BetMGM)

This is truly a complete Jaguars team on both sides of the football. Jacksonville ranks No. 2 in the NFL in total EPA, with an efficient offense and an underrated defense that has the second-most takeaways.

The Jaguars are allowing just 13.3 points per game, while the Eagles' offense ranks bottom-seven in both points and yards. That's a bona fide mismatch.

Jacksonville is healthy, confident, and accustomed to playing in London. That's why I'm comfortable backing them to cover the point spread, even at -7.5.

📡 SBR Edge: Jags creating separation

The Jaguars have won by at least eight points in seven of their last 10 regular-season games.

Eagles' injury report a horror story

On top of Lane Johnson's surprise retirement and the trade of Cam Jurgens this week, the injuries are piling up for the Eagles. Here's a list of significant players who either missed last week's loss to the Rams or exited that game early due to injury: Saquon Barkley, DeVonta Smith, Dallas Goedert, Quinyon Mitchell, Zack Baun, and Jonathan Greenard.

Philadelphia is used to having a talent advantage most weeks, but that certainly won't be the case on Sunday in London. The Jaguars will roll.

Score prediction: Jaguars 24, Eagles 15

Live Eagles vs. Jaguars odds

Eagles vs. Jaguars opening odds

Moneyline: Eagles +123 | Jaguars -151
Spread: Eagles +2.5 (+100) | Jaguars -2.5 (-120)
Over/Under: Over 44.5 (-110) | Under 44.5 (-110)

How to watch Eagles vs. Jaguars: Week 5

Date: Sunday, Oct. 11
Kickoff: 9:30 a.m. ET
Location: Tottenham Hotspur Stadium (London, England)
TV: NFL Network

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Written by:
Liam Fox

Liam Fox is a Publishing Editor for Sportsbook Review. Liam spent the past seven-plus years in the sports media industry building his NFL experience and contributing at some of North America's top outlets. His work has appeared on Sportsnet, Forbes, and Complex. He was previously an editor for nearly four years at theScore, specializing in NFL coverage. His career highlights include asking Patrick Mahomes a question at Super Bowl LV media day and shedding light on the champion Philadelphia Eagles' use of analytics through an in-depth interview with their lead data analyst. A graduate of Carleton University's Bachelor of Journalism program, you can usually find Liam writing about sports, watching sports, or playing sports.