Cowboys vs. Eagles NFL Week 1 Odds & Prediction: Expert Picks for Season Opener

One of the NFL's most storied rivalries takes center stage in Week 1 with the Eagles hosting the Cowboys at Lincoln Financial Field.

Gabe Henderson

Last Updated: May 14, 2025 7:30 PM EDT • 3 minute read

Cowboys vs. Eagles NFL Week 1 Odds & Prediction: Expert Picks for Season Opener — Pictured: Philadelphia Eagles wide receiver DeVonta Smith (6) makes a first-down catch past Dallas Cowboys cornerback Andrew Booth Jr. (25). Photo by Bill Streicher via Imagn Images.

A fierce NFC East rivalry kicks off the 2025 NFL campaign when the Dallas Cowboys come to town to face the Philadelphia Eagles from Lincoln Financial Field on Thursday, Sept. 4, at 8:20 p.m. ET (NBC). Our Cowboys vs. Eagles prediction - part of our NFL picks - highlights our best bets for the season opener.

The reigning Super Bowl champions open as 7-point betting favorites in the early-season divisional duel at our best sports betting sites. Read on for the full odds and our expert picks for the Week 1 matchup.

👉 Check out our Cowboys vs. Eagles anytime TD predictions.

📊 Cowboys vs. Eagles odds

💰 Cowboys vs. Eagles expert picks for Week 1

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✅ Against the spread pick: Eagles -6.5 (-115 via FanDuel) ⭐⭐⭐⭐
✅ Moneyline pick: Eagles ML (-298 via DraftKings) ⭐⭐⭐⭐⭐
✅ Over/Under pick: Over 46.5 (-110 via DraftKings) ⭐⭐⭐

🏈 Week 1 prediction & best bet

🎯 Score prediction: Eagles 31, Cowboys 20

Welcome to the NFL, Brian Schottenheimer. The new face of "America's Team" is being thrown into the deep end in Week 1, as Dallas hits the road to face the reigning Super Bowl champions under the lights of prime time.

We undoubtedly expect the crowd at Lincoln Financial Field to play a part in leading the Eagles to victory as they celebrate their second Super Bowl of the last decade. The Cowboys are searching for their first victory in Philadelphia since 2022, and their first win overall against the Birds since December 2023.

Schottenheimer's offense was outscored 75-13 in two games against the Eagles last season. They'll likely fare better this time around with Dak Prescott under center. The Mississippi State product boasts a 9-4 record with 24 touchdowns and eight interceptions against Philadelphia in his career.

Ultimately, though, there are too many holes on Dallas' depth chart to back the Cowboys significantly in this spot. There's no doubt they'll improve upon a dismal display from last season as they return to health, but the Eagles have the most complete roster in the NFL, full stop.

We're comfortable backing the hosts in this spot with Jalen Hurts, Saquon Barkley, and the rest of Philadelphia's offense ready to light up scoreboards once again. FanDuel offers a slightly smaller spread than other best sports betting apps, with the Eagles trading as 6.5-point favorites at -115 odds.

✅ Best bet: Eagles -6.5 (-115 via FanDuel)

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Written by:
Gabe Henderson

Gabe Henderson is a sports betting writer from Houston, Texas. He graduated from Louisiana State University in 2022 with a bachelor's degree in Mass Communication. Gabe developed an interest in sports betting while in college due to its legalization in Louisiana. He turned his passion into a career shortly after, joining The Advocate/NOLA.com as a Sports Betting Content Coordinator, where he spent two years. Gabe wore many hats before graduating as he led FanSided's coverage of Chelsea FC as a Site Expert with "The Pride of London." He was also the Editor-in-Chief of the LSU Gumbo Yearbook for two years. Gabe became a part of the SportsbookReview.com team in late 2024. He brings with him an extensive knowledge of many sports, including — but not limited to — NFL, NCAA, MLB, NBA, soccer, and UFC.