Colts vs. Vikings Prediction: Week 7 Odds, Picks & Best Bet (Oct. 25)
Last Updated: October 24, 2026 11:25 AM EDT • 3 minute read X Social Google News Link
One of the league's last undefeated teams comes off a bye to host an opponent looking to snap a losing slump in my Colts vs. Vikings prediction.
The Vikings are -6.5-point betting favorites at home from U.S. Bank Stadium in Minneapolis, Minn., leading up to Sunday's kickoff at 1 p.m. ET (CBS).
Colts vs. Vikings picks & predictions
See all of our experts' NFL picks for Week 7 based on the latest NFL odds.
| Pick | Odds | Bet size |
|---|---|---|
| Vikings -6.5 | (-105 via FanDuel) | 1.05 units to profit 1.00 unit |
| Under 41.5 | (-110 via DraftKings) | 2.20 units to profit 2.00 units |
Picks submitted: Oct. 24 at 10:45 a.m. ET. Odds subject to change
Total wagered: 3.25 units | Max profit: +3.00 units
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Colts vs. Vikings prediction & best bet
Under 41.5 (-110 via DraftKings)
The real MVP of the 5-0 Vikings has been DC Brian Flores. His aggressive blitz packages and playcalling have led Minnesota to the top of the NFL in points allowed per game (12.8) through 6 weeks.
Daniel Jones has regressed as the Colts' QB1. Indianapolis' 26-20 loss at home to the Titans in Week 6 led to the firing of long-time GM Chris Ballard. Now, the Colts will try to snap a two-game skid on the road against the league's best scoring defense.
Jonathan Taylor likely won't fare well against the Vikings. Minnesota has held 3 of 5 opponents under 70 total rushing yards. The Vikings have also forced 2+ turnovers in 4 of 5 matchups.
The Colts are plagued by turnover woes and miscues, committing 3 against the Titans, including a blocked punt that was returned for a touchdown.
Minnesota is 4-1 on point total unders this season. The total has steamed down from 44.5 to 41.5. Let's bet this total before it gets any smaller.
Let's bet Under 41.5 at -110 odds on DraftKings.
📡 SBR Edge: Skoling Under
Dating back to last season, the Vikings have gone Under the point total line in 7 of 8 games played.
Flores and Vikings Defense Shut Down Colts' Offense
Kyler Murray and the Vikings' offense are beginning to gel and face a porous Colts defense. Expect Minnesota to score at least 21-24 points against a bottom-5 Indianapolis defense.
This comes down to how the Vikings' top-ranked defense contains Colts RB Jonathan Taylor. He's a high-volume stud, but his production has been trending down. Flores and the Vikings' defense will shut down the Colts for a comfortable win at home to improve to 6-0.
Play to: Under 38.5
Score prediction: Vikings 24, Colts 13
Live Colts vs. Vikings odds
See the latest odds movement and more on our Colts vs. Vikings matchup page.
Colts vs. Vikings opening odds
- Moneyline: Colts +200 | Vikings -250
- Spread: Colts +5.5 (-110) | Vikings -5.5 (-110)
- Over/Under: Over 44.5 (-105) | Under 44.5 (-115)
Colts vs. Vikings weather
Weather will be a non-factor with this game being played in a dome at U.S. Bank Stadium.
Latest Colts vs. Vikings injuries
How to watch Colts vs. Vikings: Week 7
- Date: Sunday, Oct. 25
- Kickoff: 1:00 p.m. ET
- Location: U.S. Bank Stadium (Minneapolis, Minn.)
- TV/Streaming: CBS
Matt MacKay X social