Cardinals vs. Seahawks Prediction: Week 9 Odds, Picks & Best Bet (Nov. 8)

Arizona's deficient defense shapes our Cardinals vs. Seahawks prediction for Nov. 8. We break down the matchup and betting odds before making our best bet and projecting the final score.
Seattle Seahawks wide receiver Jaxon Smith-Njigba (11) celebrates a touchdown as we provide our Cardinals vs. Seahawks prediction.
Pictured: Seattle Seahawks wide receiver Jaxon Smith-Njigba (11) celebrates a touchdown as we provide our Cardinals vs. Seahawks prediction. Photo by Steven Bisig (Imagn Images) via Reuters Connect.
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My Cardinals vs. Seahawks prediction targets a leaky Arizona defense that can't stop anybody. On the other side, Gardner Minshew's first Cardinals start should provide an offensive spark as I target the 39.5-point total.

Sunday's matchup kicks off at 4:25 p.m. ET from Lumen Field in Seattle (FOX). The Seahawks are priced as an 8.5-point home betting favorite.


Cardinals vs. Seahawks picks & predictions

See all of our experts' NFL picks for Week 9 based on the latest NFL odds.

Pick Odds Bet size
Seahawks -8.5 -108 via DraftKings 0.5 units to profit 0.46 units
Over 39.5 -110 via BetMGM 1 unit to profit 0.91 units

Picks submitted: Nov. 5 at 11 a.m. ET. Odds subject to change.

Total wagered: 1.5 units | Profit if all picks win: 1.37 units

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Cardinals vs. Seahawks prediction & best bet

Over 39.5 (-110 via BetMGM)

The Over is always in play when the Cardinals are involved, as Arizona is allowing a league-high 29.8 points per game on defense.

Gardner Minshew led a spirited comeback victory for the Cardinals last week after taking over for Jacoby Brissett. Arizona went 3-for-3 on touchdowns in the red zone with Minshew at the controls, which should help my Over bet this week, given the Seahawks' Achilles' heel on defense. Seattle ranks worst in the NFL in red-zone TD percentage allowed at over 83%.

I love backing the Over below the key number of 40 at the best sports betting sites, which I would play to -118.

📡 SBR Edge

Five of the last six Cardinals games have gone Over their projected total.

No big scoring drop-off with Lock

No Sam Darnold this week doesn't necessarily spell disaster for Seattle's offense.

Going against one of the league's worst defenses, the Seahawks dropped 31 points on the Cardinals with Drew Lock at quarterback back in Week 2, winning by 24. I expect Lock to move the ball effectively again on Sunday.

Play to: -118, pass at 42.5.

Score prediction: Seahawks 26, Cardinals 17


Live Cardinals vs. Seahawks odds

See the latest odds movement and more on our Cardinals vs. Seahawks page.

Cardinals vs. Seahawks opening odds

  • Moneyline: Cardinals +446 | Seahawks -650
  • Spread: Cardinals +10.5 (-110) | Seahawks -10.5 (-110)
  • Over/Under: Over 44.5 (-110) | Under 44.5 (-110)

Cardinals vs. Seahawks weather

It's projected to be around 54 °F at kickoff in Seattle, with a 58% chance of precipitation. Rain could impact the passing game, but it's expected to be minimal if it happens at all.


Latest Cardinals vs. Seahawks injuries


How to watch Cardinals vs. Seahawks: Week 9

  • Date: Sunday, Nov. 8
  • Kickoff: 4:25 p.m. ET
  • Location: Lumen Field (Seattle)
  • TV/Streaming: FOX