Bills vs. Raiders Prediction: Week 6 Odds, Picks & Best Bet
Josh Allen looks to continue his NFL MVP march against a Las Vegas squad hoping to avoid a three-game losing streak, as I provide my Bills vs. Raiders prediction.
Today's kickoff is set for 4:25 p.m. ET from Allegiant Stadium in Las Vegas (CBS), with the Bills priced as a 4.5- to 5.5-point road betting favorite.
Bills vs. Raiders picks & predictions
See all of our experts' NFL picks for Week 6 based on the latest NFL odds.
| Pick | Bet size |
|---|---|
| Bills -4.5 (-110 via BetMGM) | 1 unit |
| Over 53.5 (-110 via DraftKings) | 0.5 units |
Total wagered: 1.5 units | Max profit: +1.37 units
Bills vs. Raiders prediction & best bet
Bills -4.5 (-110 via BetMGM)
Backing the Bills to win and cover the spread is my best bet for this matchup on the basis of their high-powered offense.
Buffalo ranks No. 1 in the NFL in offensive EPA/play because they have both an elite run game and an explosive passing attack.
The Raiders are feistier than expected, but their defense has looked progressively worse every week this season. This profiles as a monster game for James Cook against one of the league's worst run defenses.
While some of our other best sports betting sites have the point spread at Bills -5.5, I grabbed -4.5 at BetMGM's solid -110 odds.
📡 SBR Edge: Buffalo's run game is elite
The Bills average the second-highest yards per carry (5.4), while the Raiders rank second-last in yards per carry allowed (5.2).
Raiders overreliant on Cousins
To say that the Ashton Jeanty-led rushing attack has yet to take off under Klint Kubiak would be an understatement. The Raiders rank dead last in rushing yards per attempt.
While he's been better than expected, that puts too much pressure on 38-year-old Kirk Cousins. Las Vegas can throw the ball against Buffalo, but that lack of balance will keep the Raiders from winning or covering the spread.
Score prediction: Bills 31, Raiders 24
Bills vs. Raiders odds
Bills vs. Raiders opening odds
- Moneyline: Bills -256 | Raiders +202
- Spread: Bills -6.5 (+100) | Raiders +6.5 (-120)
- Over/Under: Over 53.5 (-110) | Under 53.5 (-110)
How to watch Bills vs. Raiders: Week 6
- Date: Sunday, Oct. 18
- Kickoff: 4:25 p.m. ET
- Location: Allegiant Stadium (Las Vegas)
- TV: CBS
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