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Joe Burrow of the Cincinnati Bengals reacts after throwing a touchdown pass against the New York Jets.
Joe Burrow of the Cincinnati Bengals reacts after throwing a touchdown pass against the New York Jets. Photo by Sarah Stier/Getty Images via AFP.

The Buffalo Bills are a home favorite against the visiting Cincinnati Bengals in the AFC Divisional Round game at Highmark Stadium on Sunday. Here is our NFL odds analysis for the highly anticipated matchup between the two scorching-hot, Super Bowl contenders.

The Kansas City Chiefs may be the No. 1 seed in the AFC, but the Bills and Bengals are both on lengthy winning streaks entering Sunday’s divisional-round clash at Highmark Stadium.

Cincinnati beat the Baltimore Ravens 24-17 last week to remain undefeated since October, while the Bills edged the Miami Dolphins 34-31 for their eighth straight victory.

Here are the best NFL odds for the AFC Divisional Round matchup featuring the Bengals and Bills via our best sportsbooks.

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Bengals vs. Bills Odds

Check out our Super Bowl odds and Super Bowl MVP odds.

Bengals vs. Bills Moneyline

Buffalo has won 11 of its last 12 games at Highmark Stadium and is a big favorite to send its fans home happy once again. If you want to back the Bills on the Moneyline, you’ll have to lay more than 2:1 on the AFC East champions. DraftKings Sportsbook is offering Buffalo -245 on the ML, the cheapest price of any of our recommended sportsbooks.

If you can’t pass up the fat underdog price to back a Bengals team that hasn’t lost since October, PointsBet is easily the place to go, with that book offer a +220 price.

Bengals vs. Bills Spread

Most sportsbooks opened Buffalo as a 4-point favorite, which would be the fewest points the Bills have been favored by at home all season. That number seemed too short for early bettors, as the point spread has moved to a near consensus of Buffalo -6. DraftKings and FanDuel Sportsbook still have the number at Bills -5.5 as of Sunday morning.

The Bills have won 11 of their last 12 games at Highmark Stadium, but they’ve failed to cover in five of their last six games as the hosts, and two of their last three wins at home have come by just a field goal. Meanwhile, Cincinnati has covered eight straight games as an underdog, part of a 20-3 against-the-spread run that dates back to last year.

Bengals vs. Bills Over/Under

The Bills-Bengals Over/Under has settled at 48.5 across our top-rated sportsbooks. The total is also lower than what the number was for the Week 17 meeting in Cincinnati that was postponed after Damar Hamlin went into cardiac arrest.

Even a 48.5 total is still high for a Bengals team that's had the Over/Under set at 47.5 or lower for nine of its last 10 games. The Bills have also had lower totals in recent weeks, with each of their last six games lined at 45 or less.

Bengals vs. Bills Trends

Cincinnati Bengals

  • 12-3 ATS in their last 15 games
  • 9-0 straight-up in their last nine games
  • 7-1 ATS in their last eight road games
  • 6-0 to the Under in their last six games as underdogs

Buffalo Bills

  • 8-0 SU in their last eight games
  • 2-5 ATS in their last seven home games
  • 5-1 to the Over in their last six home games
  • 4-0 to the Over in their last four home games

Bengals vs. Bills Game Info

Who is favored to win between Bengals and Bills?

The Bills are -225 favorites on the Moneyline to beat the Bengals.

What is the betting line for Bengals and Bills?

The Bills are 5-point favorites over the Bengals and the Over/Under for Bengals-Bills is 48.5.

How to watch Bengals and Bills

Bills vs. Bengals will be televised on CBS, with kickoff at Highmark Stadium set for 3 p.m. ET.

How to bet on Bengals and Bills?

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