🏈 49ers vs. Rams Prediction, Picks & Odds: NFL Australia Game 2026
The NFL will make history when the San Francisco 49ers and Los Angeles Rams take the pitch at Melbourne Cricket Ground in Melbourne, Australia, on Thursday, Sept. 10 at 8:35 p.m. ET (Netflix).
The matchup marks the first-ever NFL game played in Australia, and my 49ers vs. Rams prediction is backing Los Angeles as a 2.5-point betting favorite.
🏈 49ers vs. Rams prediction: NFL Australia
See the latest NFL odds and our experts' NFL picks.
| Predictions | Best odds | Confidence |
|---|---|---|
| Rams -2.5 | -120 via DraftKings | ⭐⭐⭐⭐ |
| Under 48.5 | -110 via DraftKings | ⭐⭐⭐ |
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💰 49ers vs. Rams prediction & best bet
Rams -2.5 (-120)
One of the best rivalries takes its talents down under to a time zone that's 17 hours ahead of the West Coast, so I'd expect this game to favor defense early.
Last season, the Rams' defense finished top 10 in EPA per play (-0.069) and success rate (41.8%), and it could be even better in 2026 with the additions of Trent McDuffie and Jaylen Watson.
Meanwhile, the 49ers' defense is relying heavily on players like Nick Bosa and Mykel Williams as they come off of torn ACLs against a Rams' offense led by reigning MVP Matthew Stafford.
Score prediction: Rams 24, 49ers 20
📊 49ers vs. Rams odds: NFL Australia
49ers vs. Rams odds via DraftKings.
| Team | Moneyline | Spread | Over/Under |
|---|---|---|---|
| 49ers | +124 | +2.5 (+100) | Over: 48.5 (-110) |
| Rams | -148 | -2.5 (-120) | Under 48.5 (-110) |
The NFL's first game in Australia is the first game of the season, with odds available at our best sports betting sites. With the NFL's schedule release set for Thursday, May 14, odds will be released for marquee games in the coming week. But for now, Los Angeles is the first favorite on the board for the 2026 season, and with the 49ers already being even-money at +2.5, it wouldn't be shocking if the line moves to Rams -3.5 well before the season kicks off.
Obviously, nobody can be sure how the 15-plus-hour flight and 17-hour time difference will impact these teams, but the Rams are the Super Bowl odds favorites and return the MVP (Stafford), several more Pro Bowlers on offense, and a top 10 defense. The 49ers don't have the same stability with several key players coming off injuries.
📈 49ers vs. Rams betting trends: NFL Australia
| 49ers (2025) | Statistic | Rams (2025) |
|---|---|---|
| 12-5 | W-L record | 12-5 |
| 11-6 | ATS record | 12-5 |
| 10-6-1 | O/U record | 10-6-1 |
| 5.5 | Yards per play | 6.2 |
| 5.6 | Yards allowed per play | 5.2 |
| -6 | Turnover margin | +11 |
📺 How to watch 49ers vs. Rams: NFL Australia
- Date: Thursday, Sept. 10
- Kickoff: 8:35 p.m. ET
- Location: Melbourne Cricket Ground (Melbourne, Australia)
- Streaming: Netflix
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