49ers vs. Falcons Prediction: Week 7 Odds, Picks & Best Bet (Oct. 25)
My 49ers vs. Falcons prediction has San Francisco pushing its record to 7-0, but my best bet is focused on the Over for this matchup.
Sunday's kickoff is at 1 p.m. ET from Mercedes-Benz Stadium in Atlanta (FOX). The 49ers are priced as a 3.5-point road betting favorite, while the total is one of the highest of the week at 50.5 at some sportsbooks.
49ers vs. Falcons picks & predictions
See all of our experts' NFL picks for Week 7 based on the latest NFL odds.
| Pick | Odds | Bet size |
|---|---|---|
| 49ers -3.5 | +100 via BetMGM | 0.5 units to profit 0.5 units |
| Over 49.5 | -115 via FanDuel | 1 unit to profit 0.87 units |
Picks submitted: Oct. 21 @ 11 a.m. ET. Odds subject to change.
Total wagered: 1.5 units | Max profit: +1.37 units
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49ers vs. Falcons prediction & best bet
Over 49.5 (-115 via FanDuel)
This Atlanta offense has some serious punch since Michael Penix Jr. returned to the lineup. The last four Falcons games have hit the Over - all four Penix starts.
On the other sideline, the 49ers rank third in scoring despite dealing with several injuries to their receiving corps. No matter who is on the field this Sunday, I'm confident Brock Purdy and Kyle Shanahan will keep this San Francisco offense rolling in a comfortable dome environment.
While some of our best sports betting sites have the total lined at 50.5, I grabbed a 49.5 total at FanDuel's -115 odds.
📡 SBR Edge
Falcons games have averaged over 56 points with Penix.
Falcons' pass defense getting shredded
The Falcons field a bottom-10 scoring defense, largely because of their struggling secondary. Atlanta allows the fifth-most passing yards per game entering a matchup against the red-hot Brock Purdy.
The former Mr. Irrelevant is playing the best football of his career as a genuine NFL MVP odds contender. He will get the best of this Falcons defense to win a high-scoring affair.
Play to: Over 50.5 (-105), pass at 51.5.
Score prediction: 49ers 28, Falcons 24
Live 49ers vs. Falcons odds
See the latest odds movement and more on our 49ers vs. Falcons page.
49ers vs. Falcons opening odds
- Moneyline: 49ers -232 | Falcons +185
- Spread: 49ers -4.5 (-105) | Falcons +4.5 (-115)
- Over/Under: Over 49.5 (-110) | Under 49.5 (-110)
49ers vs. Falcons weather
Weather won't have an impact on this matchup, with the game being played indoors at Mercedes-Benz Stadium.
Latest 49ers vs. Falcons injuries
How to watch 49ers vs. Falcons: Week 7
- Date: Sunday, Oct. 25
- Kickoff: 1 p.m. ET
- Location: Mercedes-Benz Stadium (Atlanta)
- TV/Streaming: FOX
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