🏀 Best March Madness Upset Picks Today: Second Round Underdog Plays for Saturday (March 21)
Last Updated: March 21, 2026 9:48 PM EDT • 1 minute read X Social Google News Link
Louisville is the only team our analysts are picking to win outright as a moneyline underdog (that game tipped off earlier today), but there’s no shortage of points worth taking in the Round of 32. Here are the best March Madness upset picks for Saturday’s second-round slate. See all of our March Madness predictions for every game this weekend.
📊 Best March Madness ATS underdog picks today
High Point +11.5 (−114) vs. No. 4 Arkansas (9:45 p.m. ET, truTV/TBS) ⭐⭐⭐⭐
Spector sees parallels between Arkansas and Thursday’s opponent Wisconsin, giving the Cinderella Panthers another live cover.
"High Point had great preparation for Arkansas by playing Wisconsin, as the two teams similarly run offense through their standout backcourt duos. The most impressive thing about Thursday’s win was that Wisconsin was previously 21-2 when shooting at least 33.3% from beyond the arc, and the Badgers shot 39.1%."
➡️ Full preview: High Point vs. Arkansas prediction & parlay
🏀 More March Madness predictions today (Saturday, March 21)
| High Point vs. Arkansas |
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