🏀 Best March Madness Upset Picks Today: Second Round Underdog Plays for Saturday (March 21)

Our analysts break down the best March Madness upset picks for Saturday's eight second-round games, including which lower seeds will win and which underdogs will cover.
Rob Martin (3) and Braden Hausen (15), featured in our High Point vs. Arkansas prediction, react during a first-round win.
Pictured: Rob Martin (3) and Braden Hausen (15), featured in our High Point vs. Arkansas prediction, react during a first-round win. Photo by Troy Wayrynen / Imagn Images.
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Louisville is the only team our analysts are picking to win outright as a moneyline underdog (that game tipped off earlier today), but there’s no shortage of points worth taking in the Round of 32. Here are the best March Madness upset picks for Saturday’s second-round slate. See all of our March Madness predictions for every game this weekend.


📊 Best March Madness ATS underdog picks today

High Point +11.5 (−114) vs. No. 4 Arkansas (9:45 p.m. ET, truTV/TBS) ⭐⭐⭐⭐

Spector sees parallels between Arkansas and Thursday’s opponent Wisconsin, giving the Cinderella Panthers another live cover.

"High Point had great preparation for Arkansas by playing Wisconsin, as the two teams similarly run offense through their standout backcourt duos. The most impressive thing about Thursday’s win was that Wisconsin was previously 21-2 when shooting at least 33.3% from beyond the arc, and the Badgers shot 39.1%."

➡️ Full preview: High Point vs. Arkansas prediction & parlay


🏀 More March Madness predictions today (Saturday, March 21)

Saint Louis vs. Michigan Louisville vs. Michigan State
TCU vs. Duke Texas A&M vs. Houston
Texas vs. Gonzaga VCU vs. Illinois
Vanderbilt vs. Nebraska High Point vs. Arkansas

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