MLB Best Home Run Predictions Today: Best HR Props, Picks, Parlay & Odds For Saturday, Sept. 26
It's the final weekend of the 2026 MLB regular season, with Saturday's 13-game slate providing some good matchups for my home run predictions today. After a two-day win streak, we're now on a two-day home run pick slump, going 0-3 again on Thursday night.
For today's MLB home run picks, I'm starting with White Sox lead-off hitter Miguel Vargas. He's recorded 18 of 33 home runs at Rate Field this season, and now he'll face Jose Quintana, who just gave up 2 home runs in his last start for the Rockies. 6.6 mph winds are also blowing into right field, not inward, creating another advantage for Vargas.
βΎ Home run predictions today: MLB HR picks & odds Sept. 26
See all of our expertsβ MLB picks based on the latest MLB odds.
| π£ Home run pick | π΅ Units | π Notes |
|---|---|---|
| Miguel Vargas (+394 via DraftKings) | 0.26u β 1.02u | Vargas has hit 18 of 33 home runs at Rate Field. |
| Travis Bazzana (+680 via FanDuel) | 0.25u β 1.70u | Michael Wacha has allowed.4 home runs in his previous 2 starts. |
| Nolan Arenado (+600 via FanDuel) | 0.25u β 1.50u | Arenado has hit 3 home runs in his last 4 contests. |
Total wagered: 0.76 units | Max profit: 4.22 units
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π£ Best home run predictions & odds today
Home run pick: Miguel Vargas (+394)
In September, Vargas has logged 4 home runs. This includes 2 home runs across his past six appearances for the White Sox.
In 206 plate appearances this year, Vargas has hit 12 home runs against left-handed pitchers. Quintana is a southpaw, allowing 3 home runs in his past 3 starts for the Rockies.
Vargas' hitting metrics are strong for power, ranked 93rd in xSLG (.498) and 88th in barrel percentage (13.1) in 2026.
Get the best number for Vargas' home run prop at +394 odds on DraftKings.
- Time: 7:10 p.m. ET
- Where to watch: MLB.TV
📡 SBR Edge: Rate Field Dingers
Vargas has hit his last 2 home runs at Rate Field, while recording 8 of his 12 home runs against lefties in his home ballpark.
π₯ More home run predictions today
Home run pick: Travis Bazzana (+680)
The Guardians lineup is going to be set up for success against Wacha at Kauffman Stadium. I'm targeting Bazzana to hit a home run due to landing an ideal matchup.
The 24-year-old 2B has hit 6 home runs in September. In 2026, the left-handed hitter has recorded 13 of his 15 home runs against right-handed pitching.
Wacha, a right-handed starter, has surrendered 6 home runs in his previous 4 starts for the Royals. Tonight's forecast at Kauffman Stadium calls for rain and 8.8 mph winds blowing into left field.
Go to FanDuel to get Bazzana's home run prop at +680 odds.
- Time: 7:10 p.m. ET
- Where to watch: MLB.TV
Home run pick: Nolan Arenado (+600)
Arenado may be the hottest home run hitter in the MLB right now. The Diamondbacks' 3B has recorded 9 home runs in September, including 3 homers in his previous 4 appearances.
The forecast at Petco Park will have 8.4 mph wind gusts blowing into right field. Arenado, a right-handed hitter, should benefit against right-handed starter, Walker Buehler.
Buehler has allowed 6 home runs in his last 5 starts for the Padres. He's given up at least 1 home run in each of these contests.
Arenado has hit 20 of his 30 home runs against right-handed pitching this season. 10 of his 14 homers at away ballparks have also been in matchups against righties.
Stay on FanDuel to bet Arenado's home run prop at +600 odds.
- Time: 8:40 p.m. ET
- Where to watch: MLB.TV
π Best home run parlay picks today
💵 Best MLB home run parlay today
- Miguel Vargas (+370)
- Travis Bazzana (+680)
- Nolan Arenado (+600)
Best odds: +25562 via FanDuel (0.10u -> 25.56u)
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Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)
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