Missouri vs. Mississippi State Prediction: Week 4 Odds, Picks & Best Bet
My best Missouri vs. Mississippi State prediction for tonight's 7:45 p.m. ET top 25 matchup focuses on the incredible offense of No. 24 Mississippi State. The defense of No. 19 Missouri has struggled at times this season, despite relatively easy competition, and I think that unit will be why the Tigers drop to 0-1 in SEC play.
Mississippi State is favored by 5.5 points in this game on the SEC Network. The contest will stream live on Fubo.
🏈 Missouri vs. Mississippi State picks & predictions
See all of our experts' college football picks for Week 4 based on the latest college football odds.
| Pick | Bet size |
|---|---|
| ATS: Mississippi State -5.5 (-108 via BetMGM) | 1.5 units to win 1.39 units |
| O/U: Over 58.5 (-110 via bet365) | 2 units to win 1.82 units |
Total wagered: 3.5 units | Max profit: 3.21 units
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💰 Missouri vs. Mississippi State prediction & best bet
Check out all of our college football predictions for more analysis across this week's slate.
Over 58.5 (-110 via bet365)
Mississippi State enters this game averaging 47 points per game, which ranks 10th-best in the nation. Led by quarterback Kamario Taylor and running back Fluff Bothwell, Mississippi State has scored at least 38 points in all three games, including two road contests against power conference competition.
That said, the Mississippi State defense has struggled and currently ranks 69th in total defense. Last week, the Bulldogs were outgained 431-393 by South Carolina, allowing 34 points.
Meanwhile, Missouri's offense has scored at least 27 points in all three games. One area where Missouri has really excelled is in turnover margin. This season, the offense has only turned the ball over twice, as the team has built up a +3 margin, tied for 23rd-best in the country.
📡 SBR Edge: Taylor's elite efficiency
Kamario Taylor has thrown 11 touchdowns and just one interception this season, with at least three touchdown passes in each game. The only player with a better touchdown-to-interception ratio is Jayden Maiava, who has played four games.
Missouri's defense stands no chance
Missouri is tied for 41st in scoring defense, despite its first three games being against an FCS opponent and the 80th- and 98th-ranked scoring offenses. While Missouri's defense doesn't rank poorly in any defensive categories, competition is a huge reason for that.
Mississippi State is averaging the second-most yards per game and the ninth-most yards per play. Bothwell has managed at least 5.5 yards per carry in all three of his games, and he's averaging 5.8 yards per rush this season. Last week, against the nation's 22nd-best rush defense, he managed 115 yards.
Score prediction: Mississippi State 38 Missouri 28
📊 Missouri vs. Mississippi State odds
See the latest college football odds for every Week 4 matchup.
Missouri vs. Mississippi State opening odds
- Moneyline: Missouri +100 | Mississippi State -120
- Spread: Missouri +1.5 (-115) | Mississippi State -1.5 (-105)
- Over/Under: Over 56.5 (-110) | Under 56.5 (-110)
📺 How to watch Missouri vs. Mississippi State: Week 4
- Date: Saturday, Sept. 26
- Kickoff: 7:45 p.m. ET
- Location: Davis Wade Stadium (Starkville, Miss.)
- TV: SEC Network
- Streaming: Fubo
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Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)
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