Northwestern vs. Indiana Prediction: Week 4 Odds, Picks & Best Bet
My best Northwestern vs. Indiana prediction focuses on the defensive performances of both of these teams so far. No. 5 Indiana ranks second in total defense, while Northwestern just held Colorado to seven points.
Indiana is favored by 20.5 ahead of tonight's 8 p.m. ET game at Memorial Stadium in Bloomington, Ind. However, the spread has dropped three points since opening at 23.5. The game will air on FOX and be live-streamed on FOX One.
🏈 Northwestern vs. Indiana picks & predictions
See all of our experts' college football picks for Week 4 based on the latest college football odds.
| Pick | Bet size |
|---|---|
| ATS: Indiana -20.5 (-115 via DraftKings) | 1 unit to win 0.87 units |
| O/U: Under 49.5 (-108 via DraftKings) | 2 units to win 1.91 units |
Total wagered: 3 units | Max profit: 2.78 units
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💰 Northwestern vs. Indiana prediction & best bet
Check out all of our college football predictions for more analysis across this week's slate.
Under 49.5 (-108 via DraftKings)
Offensively, Northwestern has impressed, averaging 37.5 points per game and dropping 41 on Colorado last week. However, Indiana hasn't allowed a single point in back-to-back games, and the Hoosiers have dominated quarterback Aidan Chiles in his career.
While with Michigan State, Chiles faced Indiana twice. He averaged 218 passing yards per game and threw two touchdowns. However, he also threw two interceptions, and in neither game did his offense top 13 points.
While Indiana's offense is averaging 48.3 points per game, the unit managed just 14 points in the first half last week against Western Kentucky. Northwestern's defense may not be as good as it was when it forced four turnovers last week, but there is no doubt that this is still the best defense Indiana has faced this season.
📡 SBR Edge
Indiana's defense hasn't allowed more than 17 points in 15 of its last 16 games against unranked opponents.
Northwestern's defense has shown improvement
I'm assuming Indiana's defense will get the better of Northwestern's offense, but it can be hard to confidently fade an offense led by Josh Hoover, Turbo Richard, and Charlie Becker. That said, Northwestern's solid defensive start to this season is no fluke.
Northwestern is allowing just 12.5 points per game, which ranks 20th in the nation. While this ranking may seem inflated by easy competition, Northwestern allowed just 19.8 points per game last year, which ranked 23rd in the nation. This is a team that hasn't allowed more than 38 points since 2024.
Score prediction: Indiana 34 Northwestern 13
📊 Live Northwestern vs. Indiana odds
See the latest college football odds for every Week 4 matchup.
Northwestern vs. Indiana opening odds
- Moneyline: Northwestern +1100 | Indiana -2100
- Spread: Northwestern +23.5 (-110) | Indiana -23.5 (-110)
- Over/Under: Over 47.5 (-110) | Under 47.5 (-110)
📺 How to watch Northwestern vs. Indiana: Week 4
- Date: Friday, Sept. 25
- Kickoff: 8 p.m. ET
- Location: Memorial Stadium (Bloomington, Ind.)
- TV: FOX
- Streaming: FOX One
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