Mississippi State vs. South Carolina Prediction: Week 3 Odds & Picks (Sept. 19)
Last Updated: September 18, 2026 4:05 PM EDT • 3 minute read X Social Google News Link
My best Mississippi State vs. South Carolina prediction expects a high-scoring affair Saturday.
South Carolina is a 3.5-point betting favorite, with kickoff from Williams-Brice Stadium in Columbia, S.C., scheduled for 4:15 p.m. ET (SEC Network).
🏈 Mississippi State vs. South Carolina picks & odds: Week 3
See all of our experts' college football picks for Week 3 based on the latest college football odds.
| 🏈 Pick | 💵 Units | 📝 Notes |
|---|---|---|
| Mississippi State +4.5 (-115 via Hard Rock Bet) | 2.3 units to win 2 units | The Bulldogs have impressed against a pair of FBS opponents behind quarterback Kamario Taylor, with 8.4 yards per play and only 4.2 yards allowed per play. |
| Over 58.5 (-110 via Caesars) | 0.55 units to win 0.5 units | A pair of exciting, mobile quarterbacks should put plenty of points on the board on Saturday in Columbia. |
| Kamario Taylor anytime TD scorer (+100 via FanDuel) | 1 unit to win 1 unit | Taylor has nine career rushing scores and is poised to score a 10th – lock this one in at even money before the line moves. |
Total wagered: 3.85 units | Max profit: +3.5 units
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💰 Mississippi State vs. South Carolina prediction & best bet
Check out all of our college football predictions for more analysis across this week's slate.
Mississippi State +4.5 (-115)
The Bulldogs might be for real. Through two games, both of which came against FBS opponents, the Bulldogs are averaging 8.4 yards per play while allowing only 4.2. Quarterback Kamario Taylor is 10th in passing efficiency score (196.3) with 12.9 adjusted yards per attempt. Saturday’s road SEC contest is a big test, but I expect them to pass with flying colors.
While South Carolina retained LaNorris Sellers, he doesn’t have much help. The Gamecocks may have ripped 8.8 yards per play against Kent State, but they struggled through the air against FCS Towson with only 3.7 yards per pass attempt. I love the Bulldogs as road dogs and will gladly take the 4.5 for -115 (53.5%) at Hard Rock
Score Prediction: Mississippi State 30, South Carolina 27
🙌 Mississippi State vs. South Carolina touchdown scorer prediction
Kamario Taylor anytime TD scorer (+100)
Sometimes you catch a sportsbook sleeping, and that’s what we’ve done here. Taylor is -150 (60%) or so at every book except FanDuel, where you can still buy him at +100 (50%) to find paydirt. He has 145 rushing yards and one rushing score to his name thus far and is a major threat to score again on Saturday.
South Carolina’s defense hasn’t faced a serious opponent yet, but Shane Beamer’s squad gave up touchdowns to Cade Klubnik and Trinidad Chambliss down the stretch last year. Taylor had eight rushing scores last year, and, in a game with a total of 58.5, is a sharp play to find paydirt at even money.
🚀 Mississippi State vs. South Carolina same-game parlay
Let’s back Taylor to have a solid game on the ground while leading Mississippi State to a road upset in the SEC with our Mississippi State vs. South Carolina same-game parlay.
💵 Mississippi State vs. South Carolina SGP picks
- Mississippi State ML
- Kamario Taylor anytime TD scorer
- Kamario Taylor 50+ rushing yards
Best odds: +394 via FanDuel (0.33 → 1.30)
📊 Live Mississippi State vs. South Carolina odds: Week 3
📺 How to watch Mississippi State vs. South Carolina: Week 3
- Date: Saturday, Sept. 19
- Kickoff: 4:15 p.m. ET
- Location: Williams-Brice Stadium (Columbia, S.C.)
- TV: SEC Network
Isaiah Sirois X social