Houston vs. Colorado Prediction: Week 11 Odds, Picks & Best Bet (Nov. 13)
Last Updated: November 13, 2026 10:30 AM EST • 3 minute read X Social Google News Link
My best Houston vs. Colorado prediction highlights why Colorado's offensive struggles are likely to continue against one of the best defenses in the Big 12. I also explain why turnovers and third-down conversions are likely to be the biggest storylines in this matchup.
No. 14 Houston is favored by 9.5 points ahead of tonight's 10:15 p.m. ET game at Folsom Field in Boulder, Colo. The game will air on ESPN and stream on ESPN Unlimited.
Houston vs. Colorado picks & predictions
See all of our experts' college football picks for Week 11 based on the latest college football odds.
| Pick | Odds | Bet size |
|---|---|---|
| Houston -9.5 | -108 via DraftKings | 2 to profit 1.85 units |
| Under 51.5 | -112 via BetMGM | 0.5 units to profit 0.45 units |
Picks submitted: Nov. 11 at 5:45 p.m. ET. Odds subject to change.
Total wagered: 2.5 units | Profit if all picks win: 2.3 units
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Houston vs. Colorado prediction & best bet
Check out all of our college football predictions for more analysis across this week's slate.
Houston -9.5 (-108 via DraftKings)
Colorado is averaging just 19.8 points per game, which ranks last in the Big 12 and 123rd in the nation. While the offense has managed at least 24 points in three of its last four games, it only put up 10 points against Arizona State's 94th-ranked scoring defense last week.
Houston is holding opponents to just 21.3 points per game. Though the defense is allowing an average of 25.6 points over its last three games, all of those opponents are averaging at least 33.0 points per game.
Offensively, Houston is converting 59.29% of third-down opportunities, the best mark in the entire country. The Cougars also lead the Big 12 in fourth-down conversion percentage (64.29%). Colorado ranks 12th in the Big 12 in third-down percentage (37.4%) and 15th in fourth-down percentage (33.33%).
📡 SBR Edge: Buffaloes' penalty issues
As if enough wasn't stacked against Colorado in this game, the Buffaloes are also the most penalized team in the conference, averaging 8.8 penalties and 75.2 penalty yards per game.
Colorado turnover troubles will continue
Houston has a turnover margin of +7, which not only leads the Big 12 but is the 14th-best mark in the nation. Meanwhile, Colorado has a turnover margin of -11, which is the worst mark in the Big 12 and the second-worst mark in the nation.
Colorado quarterback Isaac Wilson has thrown eight interceptions this season. All of them have come in his last five games. He's thrown at least one in four of those five contests, throwing at least two three times during that span.
Houston has picked off eight passes this season, so I'm expecting another multi-pick game for Wilson. And considering Conner Weigman has just two interceptions all season, there's no doubt Houston will win the turnover battle in this game.
Play to: Houston -10.5 at +100
Score prediction: Houston 34, Colorado 14
Live Houston vs. Colorado odds
See the latest odds movement and more on our Houston vs. Colorado page.
Houston vs. Colorado opening odds
- Moneyline: Houston -391 | Colorado +310
- Spread: Houston -10.5 (-110) | Colorado +10.5 (-110)
- Over/Under: Over 49.5 (-110) | Under 49.5 (-110)
Houston vs. Colorado weather
The weather won't affect this game. Temperatures are expected to stay above freezing, there's no chance of rain, and wind gusts are expected at just 7 mph.
Latest Houston vs. Colorado injuries
Houston:
- Carmycah Glass, LB - Out
Colorado:
- Naeten Mitchell, DB - Out
- Micah Welch, RB - Out
How to watch Houston vs. Colorado: Week 11
- Date: Friday, Nov. 13
- Kickoff: 10:15 p.m. ET
- Location: Folsom Field (Boulder, Colo.)
- TV/Streaming: ESPN/ESPN Unlimited
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