College Football Week 10 AI Predictions: ATS Picks & Score Projections for Top 25 Games
Our college football AI predictions for Week 10 feature projected scores and against-the-spread picks for 25 of the most intriguing games on the schedule, including several highly anticipated Top 25 showdowns.
The Week 10 slate is headlined by No. 1 Miami visiting No. 4 Notre Dame, while No. 2 Georgia travels to face No. 12 Ole Miss. Other notable matchups include No. 7 BYU at No. 3 Utah, No. 9 Alabama at No. 15 LSU, and No. 10 Texas at No. 19 Missouri.
The AI-assisted projections consider recent performance, advanced metrics, injuries, roster strength, matchup advantages, home-field edge, and current market movement. ATS selections use Kalshi's college football spread markets as of Thursday, November 5.
Follow all of SBR's college football picks throughout the season and check the latest college football odds before kickoff.
College Football Week 10 AI predictions
| Date | Kickoff (ET) | Prediction | ATS pick |
|---|---|---|---|
| Thu., Nov. 5 | 7:30 p.m. | UTSA 38, FAU 34 | FAU +7.5 |
| Thu., Nov. 5 | 8 p.m. | James Madison 41, Southern Miss 17 | James Madison -14.5 |
| Fri., Nov. 6 | 7 p.m. | SMU 37, Virginia Tech 24 | SMU -6.5 |
| Fri., Nov. 6 | 8 p.m. | Illinois 27, Nebraska 24 | Illinois +4.5 |
| Fri., Nov. 6 | 9 p.m. | New Mexico 30, Nevada 20 | Nevada +9.5 |
| Fri., Nov. 6 | 10:15 p.m. | Arizona 34, TCU 14 | Arizona -7.5 |
| Sat., Nov. 7 | Noon | Missouri 24, Texas 20 | Missouri +2.5 |
| Sat., Nov. 7 | Noon | BYU 27, Utah 24 | BYU +5.5 |
| Sat., Nov. 7 | Noon | UCLA 23, Minnesota 20 | Minnesota +5.5 |
| Sat., Nov. 7 | Noon | Syracuse 31, Clemson 27 | Syracuse +2.5 |
| Sat., Nov. 7 | 1 p.m. | Kansas State 34, Oklahoma State 27 | Kansas State +6.5* |
| Sat., Nov. 7 | 3 p.m. | South Carolina 27, Texas A&M 24 | Texas A&M +7.5 |
| Sat., Nov. 7 | 3:30 p.m. | Houston 34, Cincinnati 27 | Cincinnati +11.5 |
| Sat., Nov. 7 | 3:30 p.m. | Ohio State 34, Oregon 17 | Ohio State -7.5 |
| Sat., Nov. 7 | 3:30 p.m. | Alabama 28, LSU 24 | Alabama +5.5 |
| Sat., Nov. 7 | 6 p.m. | Boise State 42, Colorado State 30 | Colorado State +17.5* |
| Sat., Nov. 7 | 6:15 p.m. | Tennessee 38, Kentucky 20 | Tennessee -6.5 |
| Sat., Nov. 7 | 7:30 p.m. | Ole Miss 34, Georgia 27 | Ole Miss +3.5 |
| Sat., Nov. 7 | 7:30 p.m. | Notre Dame 34, Miami 23 | Notre Dame -5.5 |
| Sat., Nov. 7 | 7:30 p.m. | Iowa 20, Northwestern 13 | Iowa +2.5 |
| Sat., Nov. 7 | 7:30 p.m. | Michigan 38, Michigan State 10 | Michigan -13.5 |
| Sat., Nov. 7 | 7:30 p.m. | Colorado 24, Arizona State 20 | Colorado +3.5 |
| Sat., Nov. 7 | 7:30 p.m. | Louisville 41, Georgia Tech 17 | Louisville -14.5 |
| Sat., Nov. 7 | 7:45 p.m. | Florida 31, Oklahoma 17 | Florida -6.5 |
| Sat., Nov. 7 | 9:30 p.m. | Texas Tech 45, West Virginia 17 | Texas Tech -16.5 |
UTSA at Florida Atlantic AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| UTSA | 10 | 14 | 7 | 7 | 38 |
| Florida Atlantic | 7 | 10 | 10 | 7 | 34 |
Both teams have the offensive personnel to make this one of the highest-scoring games of Week 10. UTSA has been the more consistent team throughout the season, but Florida Atlantic can create explosive plays and keep pace. The Roadrunners should win a competitive contest without necessarily covering the spread.
ATS pick: Florida Atlantic +7.5
James Madison at Southern Miss AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| James Madison | 14 | 10 | 10 | 7 | 41 |
| Southern Miss | 3 | 7 | 0 | 7 | 17 |
James Madison remains firmly in contention in the Sun Belt and possesses one of the conference's most productive offenses. Southern Miss has struggled to find consistency against stronger competition. The Dukes should establish control early and have enough firepower to turn this into a comfortable road victory.
ATS pick: James Madison -14.5
Virginia Tech at SMU AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Virginia Tech | 7 | 3 | 7 | 7 | 24 |
| SMU | 10 | 10 | 7 | 10 | 37 |
Both teams enter this important ACC matchup with plenty to play for, but SMU's offensive consistency gives the Mustangs a significant advantage. Virginia Tech has shown it can compete defensively, though containing SMU for four quarters presents a difficult assignment. The Mustangs should create separation in the second half.
ATS pick: SMU -6.5
Nebraska at Illinois AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Nebraska | 3 | 14 | 0 | 7 | 24 |
| Illinois | 7 | 10 | 3 | 7 | 27 |
Nebraska enters this Big Ten matchup with momentum following its victory over Washington, but Illinois has been competitive against quality opponents. The Fighting Illini should benefit from home-field advantage and could create problems for Nebraska offensively. Expect a tightly contested matchup with Illinois capable of pulling off the upset.
ATS pick: Illinois +4.5
New Mexico at Nevada AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| New Mexico | 7 | 10 | 10 | 3 | 30 |
| Nevada | 3 | 7 | 3 | 7 | 20 |
New Mexico continues to exceed expectations and has established itself as a legitimate Mountain West contender. Nevada has struggled offensively but should benefit from playing at home. The Lobos have the stronger roster and should win, although covering more than two touchdowns on the road remains a difficult proposition.
ATS pick: Nevada +9.5
TCU at Arizona AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| TCU | 0 | 7 | 0 | 7 | 14 |
| Arizona | 7 | 14 | 10 | 3 | 34 |
Arizona suffered a competitive defeat to Texas Tech last weekend but remains one of the Big 12's stronger teams. TCU has struggled with consistency on both sides of the ball, creating a favorable opportunity for the Wildcats. Arizona should control this matchup defensively and build a sizable lead before halftime.
ATS pick: Arizona -7.5
Texas at Missouri AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Texas | 3 | 10 | 7 | 0 | 20 |
| Missouri | 7 | 3 | 7 | 7 | 24 |
Texas enters with momentum after consecutive SEC victories, but Missouri presents a challenging road assignment. The Tigers have been particularly dangerous defensively and should benefit from home-field advantage. With both offenses facing difficult matchups, Missouri has a realistic opportunity to keep this close and potentially win outright.
ATS pick: Missouri +2.5
BYU at Utah AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| BYU | 7 | 10 | 3 | 7 | 27 |
| Utah | 0 | 14 | 3 | 7 | 24 |
Utah remains unbeaten and enters the Holy War following a dominant 49-25 victory over Cincinnati. However, BYU has demonstrated plenty of resilience and possesses the offensive balance required to challenge the Utes. Rivalry games can produce unexpected results, and the Cougars have a realistic chance to win outright.
ATS pick: BYU +5.5
UCLA at Minnesota AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| UCLA | 7 | 6 | 3 | 7 | 23 |
| Minnesota | 3 | 7 | 3 | 7 | 20 |
UCLA remains unbeaten following its shutout victory over Nevada, but Minnesota has been competitive against strong Big Ten opponents. The Golden Gophers should be capable of slowing UCLA's offense and forcing the Bruins into longer possessions. UCLA remains the favorite, though Minnesota should keep this within one score.
ATS pick: Minnesota +5.5
Clemson at Syracuse AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Clemson | 7 | 7 | 7 | 6 | 27 |
| Syracuse | 7 | 10 | 7 | 7 | 31 |
Clemson has struggled to establish offensive consistency throughout the season, making this a difficult road assignment. Syracuse has also endured an uneven campaign but possesses enough offensive weapons to challenge the Tigers. Playing at home could provide the Orange with the opportunity to pull off an important ACC upset.
ATS pick: Syracuse +2.5
Oklahoma State at Kansas State AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Oklahoma State | 10 | 7 | 3 | 7 | 27 |
| Kansas State | 7 | 14 | 10 | 3 | 34 |
Oklahoma State continues to generate plenty of offense but surrendered 51 points in its narrow loss to Iowa State last weekend. Kansas State should benefit from playing at home and could exploit the Cowboys' defensive vulnerabilities. The Wildcats have enough offensive upside to win this Big 12 matchup outright.
ATS pick: Kansas State +6.5
Texas A&M at South Carolina AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Texas A&M | 0 | 14 | 3 | 7 | 24 |
| South Carolina | 7 | 10 | 3 | 7 | 27 |
South Carolina has built momentum behind three consecutive victories, including an impressive 42-25 win over Oklahoma. Texas A&M has struggled against stronger SEC opponents but has enough defensive talent to remain competitive. The Gamecocks should have the advantage at home, though a close finish makes the Aggies attractive.
ATS pick: Texas A&M +7.5
Cincinnati at Houston AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Cincinnati | 7 | 7 | 6 | 7 | 27 |
| Houston | 7 | 10 | 10 | 7 | 34 |
Houston returns from its bye looking to strengthen its Big 12 position, while Cincinnati hopes to rebound from a disappointing defeat against Utah. Both offenses should find opportunities to create explosive plays, making this a potentially high-scoring matchup. The Cougars should win at home without necessarily covering double digits.
ATS pick: Cincinnati +11.5
Oregon at Ohio State AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Oregon | 3 | 7 | 0 | 7 | 17 |
| Ohio State | 7 | 14 | 10 | 3 | 34 |
Ohio State suffered a disappointing defeat to USC last weekend and now faces another challenging Big Ten opponent. Oregon has also endured an inconsistent stretch, including multiple frustrating offensive performances. The Buckeyes should respond at home, with their defensive advantages creating opportunities to control possession and build a comfortable lead.
ATS pick: Ohio State -7.5
Alabama at LSU AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Alabama | 7 | 7 | 7 | 7 | 28 |
| LSU | 3 | 14 | 0 | 7 | 24 |
Alabama and LSU enter this matchup looking to improve their College Football Playoff positioning. The Tigers should benefit from home-field advantage, but Alabama possesses enough defensive talent to disrupt LSU's offense. Expect a competitive SEC battle, with the Crimson Tide having a realistic opportunity to secure a narrow road victory.
ATS pick: Alabama +5.5
Boise State at Colorado State AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Boise State | 14 | 14 | 7 | 7 | 42 |
| Colorado State | 7 | 10 | 6 | 7 | 30 |
Boise State narrowly escaped Texas State with a 46-45 victory last weekend, highlighting significant defensive vulnerabilities. Colorado State has struggled throughout the season but could exploit those weaknesses offensively. The Broncos should have enough firepower to win another high-scoring contest without necessarily covering the sizable spread.
ATS pick: Colorado State +17.5
Kentucky at Tennessee AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Kentucky | 3 | 7 | 3 | 7 | 20 |
| Tennessee | 10 | 14 | 7 | 7 | 38 |
Kentucky has been one of the SEC's biggest surprises, but traveling to Knoxville presents a difficult assignment. Tennessee has shown the offensive potential to overwhelm quality opponents, particularly at home. The Volunteers should establish their rushing attack early and can build a commanding lead if Kentucky struggles to generate scoring opportunities.
ATS pick: Tennessee -6.5
Georgia at Ole Miss AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Georgia | 3 | 10 | 7 | 7 | 27 |
| Ole Miss | 7 | 10 | 10 | 7 | 34 |
Georgia responded from its loss to Auburn with a convincing victory over Florida, while Ole Miss dismantled Auburn 45-15 last weekend. Both teams have demonstrated significant offensive potential, but the Rebels should benefit from playing at home. Ole Miss has the firepower to challenge Georgia and potentially secure an upset.
ATS pick: Ole Miss +3.5
Miami at Notre Dame AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Miami | 7 | 3 | 3 | 10 | 23 |
| Notre Dame | 7 | 14 | 10 | 3 | 34 |
Miami remains unbeaten but narrowly escaped North Carolina in a 38-35 victory last weekend, raising some questions defensively. Notre Dame enters with momentum after handling Navy and should benefit from home-field advantage. The Fighting Irish have enough offensive balance to establish control and hand the Hurricanes their first defeat.
ATS pick: Notre Dame -5.5
Iowa at Northwestern AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Iowa | 3 | 10 | 0 | 7 | 20 |
| Northwestern | 0 | 3 | 3 | 7 | 13 |
Iowa delivered an impressive defensive performance in its 30-0 victory over Wisconsin last weekend. Northwestern has been competitive throughout the season but could struggle to establish its offense against the Hawkeyes. Expect a physical, low-scoring Big Ten matchup, with Iowa capable of securing a road victory behind its defense.
ATS pick: Iowa +2.5
Michigan State at Michigan AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Michigan State | 0 | 3 | 0 | 7 | 10 |
| Michigan | 10 | 14 | 7 | 7 | 38 |
Michigan State has endured a difficult campaign and enters this rivalry matchup with just two victories. Michigan hasn't been particularly consistent either, but the Wolverines possess significant advantages defensively and at the line of scrimmage. Playing at home should allow Michigan to establish control early and cruise to a convincing victory.
ATS pick: Michigan -13.5
Colorado at Arizona State AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Colorado | 3 | 14 | 0 | 7 | 24 |
| Arizona State | 7 | 0 | 10 | 3 | 20 |
Arizona State has been competitive against strong Big 12 opponents but continues to struggle with consistency. Colorado has endured defensive problems of its own, although its offense remains capable of generating explosive plays. If the Buffaloes can limit turnovers and capitalize on scoring opportunities, they have a realistic chance to win outright.
ATS pick: Colorado +3.5
Louisville at Georgia Tech AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Louisville | 7 | 17 | 10 | 7 | 41 |
| Georgia Tech | 0 | 7 | 3 | 7 | 17 |
Louisville enters this ACC matchup with significant offensive advantages and an opportunity to strengthen its conference standing. Georgia Tech has struggled defensively against quality opponents and could find itself playing from behind early. The Cardinals should generate enough explosive plays to build a sizable lead and cover comfortably.
ATS pick: Louisville -14.5
Oklahoma at Florida AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Oklahoma | 0 | 10 | 0 | 7 | 17 |
| Florida | 7 | 14 | 3 | 7 | 31 |
Florida suffered a disappointing 27-8 defeat against Georgia last weekend but returns home for an important SEC matchup. Oklahoma has struggled offensively and was overwhelmed by South Carolina in its previous outing. The Gators should have enough defensive talent to disrupt the Sooners and establish a comfortable lead.
ATS pick: Florida -6.5
West Virginia at Texas Tech AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| West Virginia | 3 | 7 | 0 | 7 | 17 |
| Texas Tech | 14 | 14 | 10 | 7 | 45 |
Texas Tech bounced back from its loss to Cincinnati with an important victory over Arizona last weekend. West Virginia has been competitive offensively but continues to struggle defensively against stronger opponents. The Red Raiders should have significant advantages at home and can turn this into a convincing victory if they establish an early lead.
ATS pick: Texas Tech -16.5
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