Cincinnati vs. Arizona Prediction: Week 5 Odds, Picks & Best Bet
Last Updated: October 3, 2026 3:00 PM EDT • 2 minute read X Social Google News Link
My best Cincinnati vs. Arizona prediction focuses on how poorly the Cincinnati pass defense has performed this season. Arizona quarterback Noah Fifita ranks in the top 20 nationally in many key categories, and I'm expecting him to put up huge numbers against a weak secondary.
Arizona is favored by 6.5 ahead of tonight's 11 p.m. ET game at Casino Del Sol Stadium in Tucson, Ariz. The game will air on FOX and stream on FOX One.
🏈 Cincinnati vs. Arizona picks & predictions
See all of our experts' college football picks for Week 5 based on the latest college football odds.
| Pick | Bet size |
|---|---|
| ATS: Arizona -6.5 (-112 via BetMGM) | 2.5 units to win 2.23 units |
| O/U: Over 55.5 (-110 via FanDuel) | 0.5 units to win 0.46 units |
Total wagered: 3 units | Max profit: 2.69 units
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💰 Cincinnati vs. Arizona prediction & best bet
Check out all of our college football predictions for more analysis across this week's slate.
Arizona -6.5 (-112 via BetMGM)
Fifita has thrown for 1,131 yards, 11 touchdowns, and just two interceptions this year. He enters this game leading the nation's 16th-ranked passing offense, and he's completed 75.6% of his passes, averaging 8.6 yards per attempt.
Meanwhile, Cincinnati enters this game with the 117th-ranked passing defense, despite facing just one team with a top-60 passing offense. Cincinnati has allowed at least 26 points in back-to-back weeks and will now be tasked with slowing down a team averaging 32 points per game.
📡 SBR Edge: Cincy's road struggles
This is Cincinnati's first road game of the season. Over the past three seasons, Cincinnati has gone 4-9 in Big 12 road games. I expect more difficulties as JC French IV makes his first Big 12 road start as Cincinnati's quarterback.
Cincinnati's rushing attack will be stifled
Cincinnati ranks seventh in rushing yards per game and is tied for sixth in yards per carry. However, Gi'Bran Payne and Cole Tabb are about to face their first real test of the season.
To this point, Cincinnati has faced Western Carolina and the nation's 59th, 81st, and 114th-ranked rush defenses. Arizona ranks 13th in rushing yards allowed per game, giving up just 80.25 per contest. Additionally, Arizona is allowing just 3.06 yards per carry.
Arizona has already faced BYU, a team with the ninth-best rushing attack in the nation. Arizona held BYU to just 148 yards and 4.9 yards per carry. For the season, BYU is averaging 262.7 yards and 6.74 yards per carry.
Score prediction: Arizona 35 Cincinnati 21
📊 Live Cincinnati vs. Arizona odds
See the latest college football odds for every Week 5 matchup.
Cincinnati vs. Arizona opening odds
- Moneyline: Cincinnati +205 | Arizona -250
- Spread: Cincinnati +8.5 (-110) | Arizona -8.5 (-110)
- Over/Under: Over 54.5 (-110) | Under 54.5 (-110)
📺 How to watch Cincinnati vs. Arizona: Week 5
- Date: Saturday, Oct. 3
- Kickoff: 11 p.m. ET
- Location: Casino Del Sol Stadium (Tucson, Ariz.)
- TV: FOX
- Streaming: FOX One
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Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)
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