Alabama vs. LSU Prediction: Week 10 Odds, Picks & Best Bet (Nov. 7)
One of the classic rivalries in the SEC will provide another high-stakes matchup in Week 10 for my Alabama vs. LSU prediction.
No. 5 Alabama will take on No. 14 LSU, attempting to hand the Tigers their first home loss under head coach Lane Kiffin. LSU is a -6.5 betting favorite from Tiger Stadium in Baton Rouge, La., ahead of Saturday's 3:30 p.m. ET kickoff (ABC).
Alabama vs. LSU picks & predictions
See all of our experts' college football picks for Week 10 based on the latest college football odds.
| Pick | Odds | Bet size |
|---|---|---|
| Alabama +6.5 | (-105 via BetMGM) | 2.10 units to profit 2 units |
| Under 52.5 | (-108 via BetMGM) | 1.08 units to profit 1 unit |
Picks submitted: Nov. 6 at 11:30 a.m. ET. Odds subject to change.
Total wagered: 3.18 units | Profit if all picks win: 3 units
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Alabama vs. LSU prediction & best bet
Check out all of our college football predictions for more analysis across this week's slate.
Alabama +6.5 (-105 via BetMGM)
Keelon Russell has enough talent to beat any opponent he faces, which is why taking +6.5 points with Alabama feels like the right side in this matchup. Alabama's quarterback has had plenty of ups and downs in 2026, throwing for 3+ touchdowns in 3 of his previous 5 starts for the Crimson Tide.
LSU boasts a top-20 scoring defense. The Tigers also have QB Sam Leavitt under center, who has logged nearly 700 passing yards and 7 total passing touchdowns in his last 2 starts against Mississippi State and Auburn.
Alabama is in a different tier than either of those opponents Leavitt just dismantled. The Crimson Tide have held opposing quarterbacks to 1 or fewer passing touchdowns in 5 conference games, while giving up just 3.8 YPC.
LSU has dealt with less adversity than Alabama, who have repeatedly erased deficits to win games. Give me the more-tested team that is getting nearly a full touchdown on the point spread.
Bet Alabama +6.5 at -105 odds on BetMGM.
📡 SBR Edge: Crimson Tide Dominance
Alabama has won 4 of the previous 5 head-to-head games played against LSU, including 3 straight matchups, going 2-0 with head coach Kalen DeBoer.
Russell leads Alabama to a huge road win over LSU
Alabama has been searching for a big win since its 20-17 loss to Georgia. The Crimson Tide have a prime opportunity to boost its résumé by beating LSU in Baton Rouge, facing an opponent that has not played its best against top-ranked opponents this season.
Alabama's going to unlock Russell, whether with his arm or legs, to generate explosive plays. Its defense will do the rest, limiting Leavitt in the 4th quarter to wind up with a tight win, handing LSU its first home loss of 2026.
Play to: Alabama -2.5
Score prediction: Alabama 27, LSU 24
Live Alabama vs. LSU odds
See the latest odds movement and more on our Alabama vs. LSU matchup page.
Alabama vs. LSU opening odds
- Moneyline: Alabama +160 | LSU -195
- Spread: Alabama +4.5 (-102) | LSU -4.5 (-118)
- Over/Under: Over 52.5 (-110) | Under 52.5 (-110)
Alabama vs. LSU weather
The forecast for Saturday's 3:30 p.m. ET kickoff from Tiger Stadium in Baton Rouge, La. calls for 73 degrees °F with 9 mph wind and a 0% probability of precipitation. Warm and ideal conditions for a football game.
Latest Alabama vs. LSU injuries
Alabama:
- WR Ryan Coleman-Williams - Questionable
LSU:
- None
How to watch Alabama vs. LSU: Week 10
- Date: Saturday, Nov. 7
- Kickoff: 3:30 p.m. ET
- Location: Tiger Stadium (Baton Rouge, La.)
- TV/Streaming: ABC
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