NFL Odds & Week 4 Schedule | Betting Lines, Spreads and Totals for Every Game
📊 NFL odds Week 4, 2026
The NFL odds for Week 4 are via bet365.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Steelers vs. Browns (TNF) | Steelers -2.5 | PIT -155 / CLE +130 | 38.5 |
| Colts vs. Commanders (in London) | Colts -3.5 | IND -180 / WSH +150 | 47.5 |
| Cardinals vs. Giants | Giants -1.5 | ARI -110 / NYG -110 | 44.5 |
| Cowboys vs. Texans | Texans -2.5 | DAL +125 / HOU -150 | 47.5 |
| Packers vs. Buccaneers | Packers -3.5 | GB -190 / TB +160 | 39.5 |
| Jaguars vs. Bengals | Bengals -2.5 | JAX +125 / CIN -150 | 51.5 |
| Rams vs. Eagles | Rams -1.5 | LAR -130 / PHI +110 | 46.5 |
| Patriots vs. Bills | Bills -7 | NE +250 / BUF -310 | 48.5 |
| Jets vs. Bears | Bears -3 | NYJ +135 / CHI -160 | 42.5 |
| Titans vs. Ravens | Ravens -11.5 | TEN +475 / BAL -650 | 43.5 |
| Dolphins vs. Vikings | Vikings -10 | MIA +400 / MIN -550 | 38.5 |
| Broncos vs. 49ers | 49ers -2.5 | DEN +130 / SF -155 | 46.5 |
| Chiefs vs. Raiders | Chiefs -4.5 | KC -225 / LV +185 | 48.5 |
| Chargers vs. Seahawks | Seahawks -6.5 | LAC +250 / SEA -310 | 43.5 |
| Lions vs. Panthers (SNF) | Lions -3.5 | DET -190 / CAR +160 | 50.5 |
| Falcons vs. Saints (MNF) | Saints -2.5 | ATL +130 / NO -155 | 48.5 |
Our NFL picks will be locked and loaded for Week 4 as we get a fourth prime-time game in London.
- An AFC North rivalry opens the week with the Steelers a 2.5-point betting favorite over the Browns in Cleveland; kickoff from Huntington Bank Field at 8:15 p.m. ET (Prime Video)
- Sunday opens with an early one between the Colts (-3.5) and Commanders in London; kickoff from Tottenham Hotspur Stadium at 9:30 a.m. ET (NFL Network)
- Sunday wraps with the Lions (-3.5) visiting the Panthers on Sunday Night Football; kickoff from Bank of America Stadium at 8:20 p.m. ET (NBC)
- An NFC South rivalry closes the week with the Saints a 2.5-point betting favorite over the visiting Falcons; kickoff from Caesars Superdome at 8:15 p.m. ET (ESPN)
🏈 Steelers vs. Browns: Thursday Night Football
- Kickoff: 8:15 p.m. ET from Huntington Bank Stadium (Cleveland)
- How to watch: Prime Video
🏈 Colts vs. Commanders in London
- Kickoff: 9:30 a.m. ET from Tottenham Hotspur Stadium (London)
- How to watch: NFL Network
🏈 Lions vs. Panthers: Sunday Night Football
- Kickoff: 8:20 p.m. ET from Bank of America Field (Charlotte, N.C.)
- How to watch: NBC
🏈 Falcons vs. Saints: Monday Night Football
- Kickoff: 8:15 p.m. ET from Caesars Superdome (New Orleans)
- How to watch: ESPN
📈 NFL Week 4 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line with your NFL predictions. The closer you wait until kickoff to make your picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
📺 Who's playing on prime time in Week 4?
We have a fourth prime-time game in Week 4 to join Thursday Night Football, Sunday Night Football, and Monday Night Football. The NFL International Series continues with a standalone game on Sunday morning in London.
The week opens with a showdown of 2-1 AFC North teams as the Pittsburgh Steelers visit the Cleveland Browns on Thursday Night Football. We have an early kickoff on Sunday as the Indianapolis Colts and Washington Commanders tussle in London. The day wraps up with the Carolina Panthers hosting the Detroit Lions on Sunday Night Football. A 16-game slate finishes up with the 1-2 Atlanta Falcons and 1-2 New Orleans Saints on Monday Night Football.
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