Steelers vs. Bills Prediction, Picks & Best Bets: NFL Preseason Week 3 Odds

Will the Bills stay perfect this preseason in their 3rd and final preseason game against the Steelers?
Pittsburgh Steelers quarterback Drew Allar (16) throws a pass as he is featured in our Steelers vs. Bills prediction.
Pictured: Pittsburgh Steelers quarterback Drew Allar (16) throws a pass as he is featured in our Steelers vs. Bills prediction. Photo by Barry Reeger-Imagn Images
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My best Steelers vs. Bills prediction looks to navigate a preseason finale between two teams evaluating their final roster spots ahead of the regular season.

With Buffalo entering the matchup at 2-0 this preseason and several players still fighting for roster positions, could the Bills' veteran backups provide enough consistency to control this game against Pittsburgh?

I'm diving into why I think the Steelers can cover as 2.5-point underdogs against the Bills. Kickoff from Highmark Stadium in Orchard Park, New York, is set for 7 p.m. ET on NFL Network.


🏈 Steelers vs. Bills prediction: NFL preseason Week 3

See the latest NFL odds and our experts' NFL picks for every game this season.

💰 Pick ⚖️ Units 🧠 Why I bet this
Steelers +2.5 (+100 via FanDuel) 1u → 1u Drew Allar has looked fantastic this preseason, and should be able to produce points in this offense tonight.
Over 34.5 (-105 via DraftKings) 1.05u → 1u Both offenses will score tonight, and this total is too low for this game.

Total wagered: 2.05 units | Max profit: 2 units


💰 Steelers vs. Bills best bet

Steelers +2.5 (+100)

The Steelers are our pick to cover +2.5 against the Bills in Thursday’s preseason finale. Pittsburgh has plenty of motivation with roster spots still being decided, and the final preseason game gives several young players one last opportunity to make an impression. Buffalo enters 2-0 this preseason and has looked strong, but the Steelers should be able to keep this game competitive once both teams turn heavily toward their depth.

Pittsburgh’s young quarterbacks and roster-bubble players have something to prove, which can create extra intensity in a matchup where every snap matters. With the spread sitting at just 2.5 points, we only need the Steelers to win outright or lose by a field goal or less to cash the ticket.

Score prediction: Steelers 24, Bills 17


🚀 Steelers vs. Bills same-game parlay

💵 Steelers vs. Bills SGP picks

  • Steelers +2.5
  • Over 34.5

Best odds: +270 via FanDuel (0.1u -> 0.27u)


📊 Steelers vs. Bills odds: NFL preseason Week 3

Our live Steelers vs. Bills update in real time.


🚑 Steelers vs. Bills latest injuries


📺 How to watch Steelers vs. Bills: NFL preseason Week 3

  • Date: Thursday, Aug. 27
  • Kickoff: 7 p.m. ET
  • Location: Highmark Stadium (Orchard Park, NY)
  • TV/Streaming: NFL Network