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Austin Ekeler of the Los Angeles Chargers celebrates a touchdown during the first half in the game against the Atlanta Falcons, and we offer our top Bears vs. Chargers predictions based on the best NFL odds.
Austin Ekeler of the Los Angeles Chargers celebrates a touchdown during the first half in the game against the Atlanta Falcons. Photo by Todd Kirkland/Getty Images via AFP.

After the Buffalo Bills were upset last week, we were reminded to expect the unexpected on a Sunday in the NFL. To capitalize on the craziness, read on for our NFL Week 10 parlay pick.

Week 10 of the NFL season has arrived and brings several interesting betting matchups.

Even when a slate might look like a dud, however, there are usually notable results. This was most recently seen as the New York Jets upset the vaunted Bills last weekend. The NFL truly remains a league where anyone can beat anyone on any given week.

With that in mind, let’s take a look at our top NFL Week 10 parlay picks (odds via FanDuel Sportsbook).

Check out our NFL Week 10 picks roundup and our upset predictions!

NFL Week 10 Parlay Picks

Nflparlay W10

NFL Parlay Predictions Week 10

Browns +3.5 (-110)

The Cleveland Browns are coming off a bye, and don’t seem to be getting any credit for what we last saw from them. Cleveland secured a 32-13 win over the Cincinnati Bengals on Monday Night Football in Week 8. That snapped a four-game losing skid.

While Cleveland’s playoff hopes might be on life alert, it is certainly not inconceivable after a 3-5 start and with quarterback Deshaun Watson’s return looming. The Browns do need to take care of business in this game against a 6-3 Miami Dolphins squad firmly in the playoff picture.

Miami has won three games in a row, but those victories came against the Pittsburgh Steelers, Detroit Lions, and Chicago Bears. This is still a flawed team, so I like getting the points past a key number with the underdog.

Lions +3 (-115)

Looking back, we can only laugh at the hype the Lions received over the offseason. Detroit’s win total of 6.5 was the most popular Over wager in that market at most sportsbooks. Meanwhile, Chicago's win total of 6.5 garnered plenty of Under support.

Fast forward to this matchup, the Bears have a 3-6 overall record with a minus-29 point differential; the Lions are 2-6 after being outscored by a total of 46 points. The Bears were favored by 2 points in this match via the look-ahead lines at Superbook over the summer.

I think we might have adjusted these teams a bit too much as both squads are pretty bad this year. While the long-term outlook might favor the Bears, there's value in getting the key number on the Lions in a game they could win outright.

Chargers +7 (-110)

Now that we’ve covered two underdogs who are live to win, we just need the Los Angeles Chargers to stay within a touchdown on Sunday Night Football to cash this parlay. Should be easy enough, right? All the Chargers do is play close games.

Truth be told, this seems like too big of a number for two teams who have similar levels of talent on their roster. The San Francisco 49ers have the advantage of coming off a bye and playing at home, but they won’t have their normal travel advantage with another California team coming to town.

The Chargers (5-3) are a frustrating team to back as a favorite because they seem incapable of blowing teams out. But they nearly took down the Kansas City Chiefs as road underdogs in Week 2. We just need them to stay within striking distance again this weekend.

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NFL parlay picks from 11/9/2022 at 11:44 a.m. ET.