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Derrick Henry of the Tennessee Titans runs the ball against the Kansas City Chiefs in the first quarter at Arrowhead Stadium on November 06, 2022 in Kansas City, Missouri.
Derrick Henry of the Tennessee Titans runs the ball against the Kansas City Chiefs in the first quarter at Arrowhead Stadium on November 06, 2022 in Kansas City, Missouri. Photo by David Eulitt/Getty Images via AFP.

The Denver Broncos are set to return from their bye week as they head to Nashville to take on the Tennessee Titans. Here are our top picks as the 5-3 Titans host the 3-5 Broncos in Week 10.

Broncos country is still waiting for quarterback Russell Wilson and the rest of the team to ride, which could be a tough proposition against the Titans on the road. Denver is still reeling from the loss of running back Javonte Williams, and there’s no telling whether or not the passing game will improve either.

Tennessee suffered a tough overtime loss to the Kansas City Chiefs last week but had won five straight games before that. Running back Derrick Henry has naturally been the star, rushing for a league-high 870 yards and nine touchdowns through eight games. Will the Broncos' middling run defense be able to contain him?

Here are our top Broncos-Titans NFL picks for Week 10 (odds via DraftKings Sportsbook and FanDuel Sportsbook; pick confidence based on a 1-to-5-star scale).

Check out all of our NFL picks for Week 10, along with our best bets and touchdown scorer props.

Broncos vs. Titans Game Info

Date: Sunday, Nov. 13, 1 p.m. ET
TV: CBS
Location: Nissan Stadium, Nashville, TN
Weather: 46 degrees, 0% chance of precipitation, 4-mph winds

Broncos vs. Titans Odds

Broncos vs. Titans Odds Analysis

The Over/Under opened at 40.5 before plummeting to 36.5 as of Thursday afternoon. The Under has drawn 57% of the tickets and 92% of the cash.

Tennessee opened as a 1.5-point favorite, but the spread has grown to -2.5. Some sportsbooks are offering -3, however, -2.5 is naturally the better value and should be targeted.

Broncos vs. Titans Picks

Sbr Betting TicketThree Picks

Broncos vs. Titans ATS Pick

Titans -2.5 (-105) ★★★★★

Tennessee hasn’t missed a beat in recent weeks, even after being forced to turn to rookie quarterback Malik Willis. Starting quarterback Ryan Tannehill (ankle) sat out each of the last two weeks but could return this Sunday so long as he logs enough practice reps. He was a full participant on Thursday, which bodes well for his Week 10 chances.

Willis didn’t throw a single touchdown with a lowly completion rate of 42.3% in two starts, so there’s an incentive to bring Tannehill back into the fold sooner than later. Tennessee went 1-1 in his absence.

Luckily, the Titans have a reliable run game they can turn to in times of trouble. In addition to Henry, running back Dontrell Hilliard is very capable of racking up rushing yards. Rookie wide receiver Treylon Burks (toe) plans to return this week as well, which would be a big boost. The Broncos lost four straight games before Week 8's win over the Jacksonville Jaguars. They don’t have a clear avenue to success — especially given their abysmal 1-3 road record, including the neutral-site game.

Broncos vs. Titans O/U Pick

Under 36.5 (-110) ★★★★★

Denver and Tennessee have both been stingy when it comes to scoring and allowing points. The Broncos are averaging just 15.1 points per game on offense but also allow just 16.5 PPG. The Titans are scoring 18.6 points per game and yielding just 19.8. Neither squad has a quarterback that has been converting on scoring drives with regularity this season, and a fairly solid defense on each side will only strengthen the chances of point suppression.

In fact, Tennessee’s defense has allowed 20 or more points in a game on only two occasions since a 41-7 spanking at the hands of the Buffalo Bills in Week 2. Pedestrian quarterback play has been moot thanks to a fantastic ground game and the aforementioned defense, which is why the Titans are still in a playoff spot at all.

There’s a reason oddsmakers have set this line so low, and a lot would have to go right for the total to be eclipsed.

Broncos vs. Titans Prop Pick

Henry 100+ rushing yards, 1+ rushing TDs (+200) ★★★★★

There have never been concerns about Henry’s game when he’s on the field, however, questions of durability arose following a Week 8 injury that derailed him for the rest of last season. Fortunately, the 28-year-old has picked up right from where he left off. He’s rushed for over 100 yards in each of his last five games and has scored a touchdown in all but two games this season.

Denver’s defense cannot typically be pushed around, but it also isn’t as strong as it’s been in recent years. In Week 8, Jaguars rookie running back Travis Etienne torched the Broncos defense to the tune of 156 rushing yards and a touchdown. Henry is matchup-proof, and this could be a juicy one which makes the favorable odds of this prop very enticing.

Where to Bet on Broncos vs. Titans Picks

Here are our top-rated sportsbooks:

Broncos-Titans picks made 11/10/2022 at 5 p.m. ET