Cardinals vs. Dodgers Prediction & Picks: MLB Odds for Wednesday, Sept. 2

My Cardinals vs. Dodgers prediction breaks down the best bets, player props, home run pick, and same-game parlay I’m betting today.
Los Angeles Dodgers pitcher Yoshinobu Yamamoto (18) pitches as he is featured in our Cardinals vs. Dodgers prediction.
Pictured: Los Angeles Dodgers pitcher Yoshinobu Yamamoto (18) pitches as he is featured in our Cardinals vs. Dodgers prediction. Photo by Dale Zanine-Imagn Images
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Our Cardinals vs. Dodgers predictions and odds are set for a late-night matchup at Dodger Stadium, with first pitch scheduled for 10:10 p.m. ET. Los Angeles will send Yoshinobu Yamamoto to the mound, giving the Dodgers an established starter to lead the pitching staff in this matchup.

The Cardinals’ starting pitcher is still TBD, leaving some uncertainty surrounding the opposing side of the pitching matchup. With Los Angeles playing at home and Yamamoto taking the ball, there are several factors to consider when evaluating the moneyline, run line and total for this National League showdown.


⚾ Cardinals vs. Dodgers picks & odds today

See all of our experts’ MLB picks based on the latest MLB odds;

⚾ Pick 💵 Units 📝 Notes
Dodgers moneyline (-250 via FanDuel) 2.5u → 1u The Dodgers should have no problem defeating the Cardinals with their ace Yamamoto on the bump, especially with the Cardinals expecting to throw a bullpen game.
Mookie Betts 2+ hits, runs, and RBI's (-150 via DraftKings) 1.5u → 1u Mookie Betts has been swinging an extremely hot bat, that will continue tonight.
Shohei Ohtani to hit a home run (+300 via FanDuel) 1u → 3u With the Cardinals deploying a bullpen game, it is the perfect opportunity to back Ohtani.

Total wagered: 5 units | Max profit: 5 units

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🏆 Who will win Cardinals vs. Dodgers?

The Dodgers are the clear side to back thanks to Yoshinobu Yamamoto taking the mound and giving Los Angeles a significant advantage in the starting pitching matchup. Playing at Dodger Stadium should provide another boost, with the Dodgers’ lineup capable of putting pressure on the Cardinals throughout the game. Los Angeles also has the deeper overall roster and should be able to capitalize on its advantages at the plate and on the mound to secure the win.

Score prediction: Dodgers 7, Cardinals 3


💰 Cardinals vs. Dodgers prediction & best bet

Dodgers moneyline (-250)

The Dodgers will win this game because they have a major advantage on the mound with Yoshinobu Yamamoto getting the start. Yamamoto gives Los Angeles a reliable ace capable of limiting the Cardinals’ offense and keeping the game under control from the opening inning. Meanwhile, the Dodgers’ lineup has the depth and power to consistently create scoring opportunities against an opposing starter who is still TBD.

Playing at Dodger Stadium provides another advantage, while Los Angeles’ overall roster is simply stronger. With superior pitching, a deeper lineup and home-field advantage, the Dodgers are the team to back.

📡 SBR Edge: Yamamoto day

Yoshinobu Yamamoto is worth backing because his combination of swing-and-miss stuff, command and ability to work deep into games gives the Dodgers a major advantage on the mound. With Yamamoto setting the tone early, Los Angeles has a strong opportunity to control the game and put itself in position to secure another win at home.


🔥 Best Cardinals vs. Dodgers player prop bet

Mookie Betts 2+ hits, runs, and RBI's (-150)

Backing Mookie Betts to record 2+ hits, 2+ runs and 2+ RBI is an aggressive same-game prop, but the upside is clear given his role in the Dodgers’ lineup. Betts consistently finds himself in the middle of Los Angeles’ most dangerous offensive opportunities, giving him multiple chances to contribute in different ways.

Two hits would give him a strong foundation to cash the prop, while his ability to score runs increases when the hitters behind him are producing. The RBI component is more challenging, but Betts should have plenty of opportunities if the Dodgers’ offense puts runners on base. With Los Angeles favored at home, we like Betts to be heavily involved offensively and believe this plus-value prop is worth considering against the Cardinals.


💣 Cardinals vs. Dodgers home run prediction

Shohei Ohtani to hit a home run (+300)

We are backing Shohei Ohtani to hit a home run tonight because his elite power gives him the ability to change the game with one swing. Ohtani is always a threat in the batter’s box, particularly when he gets a pitch in a favorable location that he can drive into the seats. Hitting in the heart of the Dodgers’ lineup should also provide him with multiple opportunities to attack the opposing pitcher and see quality pitches throughout the game.

With Los Angeles expected to generate plenty of offensive chances at home, Ohtani should have several opportunities to do damage. His combination of bat speed, raw power and hard-contact ability makes the home run prop worth backing.


🚀 Cardinals vs. Dodgers same-game parlay

I expect a Dodger domination tonight at Dodger Stadium, which will cash all of the legs of our parlay.

💵 Cardinals vs. Dodgers SGP picks

  • Dodgers moneyline (-250)
  • Mookie Betts 2+ hits, runs, and RBI's (-150)
  • Shohei Ohtani to hit a home run (+300)

Best odds: +580 via FanDuel (.1u -> .58u)


💵 My betting record for MLB picks

All MLB picks, including SGPs, have been tracked since March 7, 2026.

Bet type Record Net profit ROI
Overall 39-30-1 +1.2 units ✅ 51.8% ✅
Game picks 24-12-0 +7.9 units ✅ 56.99% ✅
Player props 12-12-1 -6.3 units ❌ 48.91% ❌
Parlays 3-6-0 +3.6 units ✅ +88.88% ✅

📊 Live Cardinals vs. Dodgers odds


📈 Cardinals vs. Dodgers betting trends

Cardinals Statistic Dodgers
69-70 W-L record 82-56
76-63 Run line record 55-83
60-78-1 O/U record 63-74-1
4-6 Last 10 games 5-5
4.23 Team ERA 3.62
.240 Team batting avg. .258
.696 OPS .757

🚑 Cardinals vs. Dodgers injuries


📺 How to watch Cardinals vs. Dodgers

  • Date: Wednesday, Sept. 2
  • First pitch: 10:10 p.m. ET
  • Ballpark: Dodger Stadium (Los Angeles)
  • TV: MLB.TV
  • Streaming: MLB.TV
  • Cardinals starter: TBD
  • Dodgers starter: Yoshinobu Yamamoto (12-8, 2.56 ERA)