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Caleb Williams of the USC Trojans at United Airlines Field at the Los Angeles Memorial Coliseum.
Caleb Williams of the USC Trojans at United Airlines Field at the Los Angeles Memorial Coliseum. Ronald Martinez/Getty Images/AFP.

USC looks for revenge for its mid-October loss to Utah in Salt Lake City when the two rivals clash in Las Vegas on Saturday. Check out our top Utah-USC college football picks.

The task at hand for USC (11-1) on Friday while ranked No. 4 in the latest College Football Playoff rankings is a simple one: Win and you’re in. Can Utah (9-3) beat the Trojans again to end their conference rival’s CFP dreams?

Here are our Utah-USC college football picks for Week 14 (odds via DraftKings Sportsbook, FanDuel Sportsbook, and BetMGM; Pick confidence is based on a 1-to-5-star scale).

Check out our college football best bets and all of our top picks for Week 14!

Utah vs. USC Game Info

Date: Friday, Dec. 2, 8 p.m. ET
Location: Allegiant Stadium, Paradise, NV
Weather: Indoors

Utah vs. USC Odds

Utah vs. USC Odds Analysis

The line on Utah-USC opened as a pick’em before action on the Trojans pushed the spread in their favor. USC is listed as 2.5-point favorites at BetMGM and FanDuel, while DraftKings is offering the Trojans at -3 after 79% of the money has been wagered on the school.

The total opened at 67 and has remained there at BetMGM. The number has been bet up to 67.5 at FanDuel and DraftKings. Currently, 95% of the money on the total has gone to the Over.

Check out Bet365's "Win and You're In" boost for this weekend's slate of games.

Utah vs. USC Picks

Utah vs. USC ATS Pick

USC -2.5 (-115)★★★

Caleb Williams produced arguably his best game of the year in a losing effort the first time USC matched up against Utah in 2022, throwing five touchdown passes during a 43-42 road loss for the Trojans. Utah has produced the 10th-ranked rushing offense in FBS. But Cameron Rising and the team's passing game torched USC for more than 400 passing yards on Oct. 15.

USC’s defensive issues still haven't been resolved. The Trojans rank 65th in the nation in defensive efficiency, easily the worst among the programs still in play to reach the College Football Playoff. But USC's offense with its No. 1-ranked efficiency can overcome that weakness during the rematch.

BetMGM offers the most favorable option for USC backers at -2.5 with -115 odds. FanDuel also lists USC at -2.5, but the odds to back the Trojans there are inflated to -118. If you aren’t worried about the hook, DraftKings offers attractive -105 odds on the Trojans, but with the line pushed to -3.

Utah vs. USC O/U Pick

Over 67 (-110)★★★★

The Utes’ thrilling win over USC in the first meeting between the two squads this season ended with 85 points, so this gaudy total isn't surprising. Though Utah’s offense has produced three games below 27 points in 2022, USC’s defense isn’t solid enough to prevent a shootout.

Utah rushes for more than 200 yards per game and has already demonstrated an ability to attack USC through the air. USC averages 42.5 points per game and scored below 38 points only twice all campaign. If the Utes can get within a possession of their 36.4 points-per-game average, the Over should be in solid shape.

BetMGM is listing the best number for Over bettors at 67 with -110 odds. That’s half a point lower than the 67.5 posted at DraftKings and FanDuel, and with identical -110 odds.

Utah vs. USC Prop Pick

Rising Over 268.5 passing yards (-114) ★★★★

Cameron Rising has only cleared this passing total twice all season. But there are a couple of important factors indicating he's well-positioned to do it again on Friday.

Though Rising’s only game all year with 300-plus passing yards came against USC, he threw for a season-high 405 yards during that matchup. Secondly, USC has allowed opposing quarterbacks to clear 300 yards in five of its last six games. That’s quite a cushion beyond Rising’s FanDuel line of 268.5.

DraftKings has set the line at 280.5 with -105 odds. So if you like the Over, bet it at FanDuel instead.

Where to Bet on Utah vs. USC Picks

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Utah-USC picks made 12/1/2022 at 12:56 p.m. ET