Skip to main content
Cameron Rising of the Utah Utes throws under pressure from Jonah Tavai of the San Diego State Aztecs during the first half of their game on September 17, 2022 at Rice Eccles Stadium in Salt Lake City, Utah.
Cameron Rising of the Utah Utes throws under pressure from Jonah Tavai of the San Diego State Aztecs during the first half of their game on September 17, 2022 at Rice Eccles Stadium in Salt Lake City, Utah. Photo by Chris Gardner/Getty Images via AFP.

Clemson and Wake Forest battle in a matchup that could determine who earns a berth in the conference championship game. Read on for our best ATS bets for Week 4’s college football action.

While Week 2 was filled with plenty of upsets, Week 3 was a bit chalky, as three AP top-13 teams (No. 11 Michigan State, No. 12 BYU, No. 13 Miami) all lost road contests, but all were underdogs going into their games.

Below, we offer our top ATS bets for Week 4 in college football (odds via FanDuel Sportsbook, DraftKings Sportsbook, and BetMGM; pick confidence based on a 1-to-5-star scale).

Top ATS Bets of Week 4

Top ATS Predictions of Week 4

Wake Forest +7.5 (-110) ★★★★

Wake Forest ran for just 21 yards on 26 carries against Liberty, which is ominous considering it averaged 1.2 yards per carry (36 yards on 31 carries) in last year’s 48-27 loss to Clemson. But this Tigers offense still does not inspire much confidence. If one of quarterback D.J. Uiagalelei’s best performances last year was an 11-for-19 passing and 208-yard game against the Demon Deacons, he is the least trustworthy quarterback of any highly-ranked team.

Look for Wake Forest’s Sam Hartman (625 yards passing, seven touchdowns in two starts) to make enough plays and for the Demon Deacons to keep pace with the Tigers. This will be Wake Forest's most hyped-up crowd in years as it aims to snap a 13-game losing skid against Clemson.

The point spread becomes a lot more enticing if one can get the hook, and with FanDuel and DraftKings the only sportsbooks offering +7.5, we are tabbing the latter as our go-to sportsbook as its -110 juice is more desirable than FanDuel’s -120.

Check out the latest comprehensive and most trusted Sportsbook Reviews by SBR.  

Iowa State -1.5 (-115) ★★★

In one of the “fishiest” lines of the week, Baylor is a road underdog against an Iowa State team that was picked to finish sixth in the conference preseason poll, receiving one first-place vote. However, given Baylor’s poor splits on the road under head coach Dave Aranda, the Cyclones are more deserving favorites than one would initially think.

Heading into the BYU game two weeks ago, since 2020, Baylor was 12-2 with 34.4 points per game and 195.9 rush yards per game in home or neutral site games. However, on the road, the Bears were 3-7 and averaged 24.1 PPG and 139.9 rushing yards per game. The Bears then lost a 26-20 overtime game against a short-handed BYU team without its two best receivers and were held below three yards per carry (152 yards on 52 attempts). 

Iowa State is a physical team averaging 156.0 yards per game on the ground and had a near upset in Waco last year, losing 31-29. However, this Bears team is not as stout on either line of scrimmage as last year’s championship squad, and the home environment in Ames will make all the difference.

Utah -14.5 (-110) ★★★

Sometimes a coaching change mid-season can galvanize a team and instill energy that was not there before. Other times it can play out exactly as it did in last week’s Nebraska-Oklahoma contest, where oddsmakers thought the Cornhuskers would play inspired after Scott Frost’s departure, only to see them lose by 35 points at home. We expect this game to play out similarly after Arizona State fired Herm Edwards over the weekend.

The Sun Devils are coming off one of the more embarrassing losses by a Power 5 team, as a 30-21 home loss to Eastern Michigan ultimately did Edwards in. Utah is a red-zone turnover against Florida away from being 3-0 and likely a top-six team heading into this matchup. The Utes have held back-to-back opponents to seven points and fewer than 200 total yards.

We look for them to embarrass Arizona State in interim coach Shaun Aguano’s first game.

Where to Bet on College Football ATS Picks

Here are our top-rated sportsbooks:

FanDuel Sportsbook
Caesars Sportsbook
DraftKings Sportsbook

SEE ALSO: All picksodds, and sports betting news. Be sure to check out’s community forums and betting tools.

College football top ATS bets from 9/19/2022 at 8:50 a.m. ET.