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Nathan MacKinnon of the Colorado Avalanche waits for a faceoff against the Vegas Golden Knights and we provide a look at our top odds and predictions for Penguins vs. Avalanche on Wednesday.
Nathan MacKinnon of the Colorado Avalanche waits for a faceoff against the Vegas Golden Knights. Photo by Ethan Miller/Getty Images via AFP.

The Colorado Avalanche have won six straight games and are set to host a struggling Pittsburgh Penguins team. Read on for our best Penguins vs. Avalanche picks based on the best NHL odds.

The Avalanche have been bitten by the injury bug this season, but they’ve worked through it. The Avs have won six straight games but may be without Cale Makar again Wednesday, and Evan Rodrigues has already been ruled out.

On the other hand, the Penguins’ last dance might be cut short. Sidney Crosby & Co. have lost four straight games and scored a total of three goals in their last three contests.

Here is our best Penguins vs. Avalanche NHL pick (odds via BetMGM; pick confidence based on a 1-to-5-star scale).

Penguins vs. Avalanche pick

Avalanche ML (-160 via BetMGM)

These are two teams headed in opposite directions. The Avalanche, even through all of their injuries, are gearing up for another Stanley Cup run, while the Penguins’ playoff hopes continue to dwindle.

Goaltending has been one of Pittsburgh’s main issues, and that could continue Wednesday. Tristan Jarry is likely to start in the first half of a back-to-back, and he’s been poor as of late. He is 0-3 in his last four appearances, allowing 13 goals on 79 shots (.835 save percentage).

Colorado starter Alexander Georgiev has been great in his first season with the Avs. He boasts a 32-14-5 record with a 2.53 GAA and .920 SV%.

Home-ice advantage is extra important in the Mile High City. Colorado is 19-11-5 at home while Pittsburgh is a paltry 15-15-5 on the road.

Penguins vs. Avalanche best odds

BetMGM (-160)

DraftKings FanDuel BetMGM Caesars PointsBet
Avalanche ML Avalanche ML Avalanche ML Avalanche ML Avalanche ML
-165 -162 -160 -160 -160

The odds have stabilized a bit as of Wednesday morning with the Avalanche ranging from -160 to -165 at our top-rated sportsbooks.

Penguins vs. Avalanche odds

Penguins vs. Avalanche odds analysis

The Avalanche opened as bigger favorites but the line has come down due to the injury news, despite most of the tickets and money coming in on Colorado.

The total is set at 6.5 across the board, with the Under slightly favored, ranging from -114 to -120.

Penguins vs. Avalanche game info

Date: Wednesday, March 22, 8 p.m. ET
Location: Ball Arena, Denver, CO

Penguins-Avalanche pick made 3/22/2023 at 11:05 a.m. ET.

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