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Derrick Henry of the Tennessee Titans runs with the ball as Jonathan Owens of the Houston Texans.
Derrick Henry of the Tennessee Titans runs with the ball as Jonathan Owens of the Houston Texans. Photo by Carmen Mandato/Getty Images via AFP.

The Tennessee Titans visit the Philadelphia Eagles on Sunday in a Week 13 battle of division leaders. Check out our Titans-Eagles NFL picks based on the top odds.

Despite their loss to the Cincinnati Bengals last week, the Titans (7-4) are still 2.5 games clear of the Indianapolis Colts in the AFC South standings. Tennessee is now just 1-4 against teams that currently have winning records and will be put to the test by the 10-1 Eagles, who have won back-to-back games since suffering their first loss. Philadelphia is the highest-scoring team in the NFC, with 303 points scored.

Here are our Titans-Eagles NFL picks for Week 13 (odds via PointsBet; pick confidence based on a 1-to-5-star scale).

Check out our NFL best bets and all of our top picks for Week 13!

Titans vs. Eagles Game Info

Date: Sunday, Dec. 4, 1 p.m. ET
Location: Lincoln Financial Field, Philadelphia, PA
Weather: 44 degrees, 1% chance of precipitation, 9-mph WNW wind

Titans vs. Eagles Odds

Titans vs. Eagles Odds Analysis

This line has done nothing but move in Tennessee’s favor, lowering from Eagles -6 to as low as -5 at some sportsbooks. The betting splits justify the line movement, as the Titans are popular underdogs. Tennessee has attracted 70% of the bets and 72% of the cash.

The total has held firm at 44.5 points all week despite 72% of the tickets and 82% of the handle backing the Over.

Titans vs. Eagles Picks

  • Spread: Titans +5.5 (-107)
  • Over/Under: Over 44.5 (-107)
  • Prop bet: A.J. Brown Over receiving yards (Off)

Titans vs. Eagles ATS Pick

Titans +5.5 (-107) ★★★

Tennessee is a matchup nightmare for Philadelphia, as it ranks third against the run (84.5 yards per game allowed), while the Eagles entered last week with a 26th-ranked run defense, per Football Outsiders’ DVOA.

Derrick Henry is coming off a week in which he had seven carries for zero or negative rushing yards. Among his 17 carries, none went for longer than nine yards. However, in Weeks 1 to 11, Henry averaged 23 rushes per game, 101 rush yards per game, 4.4 yards per rush, and had 10 touchdowns. Thus, we expect Henry to get back to that form against Philadelphia.

Last week’s loss was Ryan Tannehill’s first since Week 2, as he had won six straight starts. In addition, the Titans had covered eight consecutive games before last week, so we trust them to bounce back in this underdog role.

We are heading to PointsBet for this wager not just because it has one of the only +5.5s remaining but also charges the least juice.

Titans vs. Eagles O/U Pick

Over 44.5 (-107) ★

Tennessee has held eight consecutive opponents to 20 or fewer points for the first time since 2007-08, but Philadelphia will challenge it in ways not many teams can. Jalen Hurts has completed 67.3% of his passes, with 17 touchdowns and a QBR of 68.2.

He has accomplished that in 11 games, compared to a 61% completion percentage, 16 passing touchdowns, and a 55 QBR in 15 games last year. In addition, Hurts became the fourth quarterback since 1966 with 150-plus passing yards and 150-plus rushing yards, and he has shown an innate ability to extend plays.

On the other side, Tennessee scored zero touchdowns on three red-zone possessions last week, so we expect regression from its offense. The Titans also now face an Eagles secondary without safety C.J. Gardner-Johnson, who will miss weeks with a lacerated kidney. He leads the NFL with six interceptions and is a considerable loss.

Titans vs. Eagles Prop Pick

Brown Over receiving yards (Off) ★★★★★

A.J. Brown had a relatively quiet game amid Philadelphia’s 40-point outburst last week, as they focused more on the running game and totaled 363 rushing yards (the team’s most since 1948).

However, Brown was battling an illness all week and still managed 46 yards and a touchdown. He will be motivated to torch his former team, and he should have the opportunity, as the Titans allow the third-most targets (21.4) per game to opposing wide receivers.

Where to Bet on Titans-Eagles Picks

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Titans-Eagles picks made 12/1/2022 at 6:17 a.m. ET.