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Rams vs. Broncos Prediction: Week 3 Odds, Picks & Best Bet

Our Rams vs. Broncos prediction for Week 3 includes our best bet, projected score, and the latest odds for Sunday's matchup.

Liam Fox

Last Updated: September 26, 2026 5:00 PM EDT • 2 minute read

Pictured: Los Angeles Rams defensive tackle Aaron Donald (99) looks on as we provide our Rams vs. Broncos prediction. Photo by Gary A. Vasquez via Imagn Images.

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Two conference championship runners-up meet on Sunday Night Football, with my Rams vs. Broncos prediction backing a strong defensive performance from both teams.

Kickoff is set for 8:20 p.m. ET from Empower Field at Mile High in Denver (NBC/Peacock), with the Rams priced as a 2.5-point road betting favorite.

🏈 Rams vs. Broncos picks & predictions

See all of our experts' NFL picks for Week 3 based on the latest NFL odds.

Pick	Bet size
Rams -2.5 (-110 via DraftKings)	0.5 units
Under 44.5 (-105 via DraftKings)	1 unit

Total wagered: 1.5 units | Max profit: 1.41 units

💰 Rams vs. Broncos prediction & best bet

Under 44.5 (-105 via DraftKings)

This has all the makings of a low-scoring prime-time matchup.

Denver's defense has been a formidable unit the last few seasons, particularly at Mile High. The Broncos have allowed an average of less than 20 points per home game since 2024.

The Rams got right on offense last week, but they aren't without their concerns on that side of the ball. L.A. has four turnovers already and will likely be without All-Pro WR Puka Nacua for a second straight game.

While some of the best sports betting sites have the total at 45.5, I'm comfortable backing Under 44.5 at DraftKings to get better odds.

📡 SBR Edge: Under trends

Rams and Broncos games are a combined 4-0 to the Under this season.

Bo Nix on regression watch

Broncos quarterback Bo Nix has been erratic through two games, an overlooked early development of the 2026 season. Nix ranks 39th in EPA/play out of 43 qualified QBs.

The Rams' offense will have its work cut out against the Broncos, but it will be L.A.'s own defense that leads them to win and cover the spread in Denver on Sunday night.

Score prediction: Rams 23, Broncos 17

📊 Live Rams vs. Broncos odds

See the latest NFL odds for every Week 3 matchup.

Rams vs. Broncos opening odds

Moneyline: Rams -136 | Broncos +111
Spread: Rams -2.5 (-115) | Broncos +2.5 (-105)
Over/Under: Over 45.5 (-110) | Under 45.5 (-110)

📺 How to watch Rams vs. Broncos: Week 3

Date: Sunday, Sept. 27
Kickoff: 8:20 p.m. ET
Location: Empower Field at Mile High (Denver)
TV: NBC
Streaming: Peacock

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Written by:
Liam Fox

Liam Fox is a Publishing Editor for Sportsbook Review. Liam spent the past seven-plus years in the sports media industry building his NFL experience and contributing at some of North America's top outlets. His work has appeared on Sportsnet, Forbes, and Complex. He was previously an editor for nearly four years at theScore, specializing in NFL coverage. His career highlights include asking Patrick Mahomes a question at Super Bowl LV media day and shedding light on the champion Philadelphia Eagles' use of analytics through an in-depth interview with their lead data analyst. A graduate of Carleton University's Bachelor of Journalism program, you can usually find Liam writing about sports, watching sports, or playing sports.