49ers vs. Cowboys Prediction: Week 10 Odds, Picks & Best Bet (Nov. 15)
The 49ers look to improve upon their NFC-best 7-1 record when visiting the 4-5 Cowboys Sunday, but my 49ers vs. Cowboys prediction expects the home underdog to keep things close, especially with San Francisco dealing with numerous injury concerns among its top pass catchers.
Kickoff from AT&T Stadium in Arlington, Texas, is set for 4:25 p.m. ET (FOX). The 49ers are as high as a 4.5-point betting favorite, and the total is the highest of any game on the Week 10 slate at 55.5 points.
49ers vs. Cowboys picks & predictions
See all of our experts' NFL picks for Week 10 based on the latest NFL odds.
| Pick | Odds | Bet size |
|---|---|---|
| Cowboys +4.5 | -117 via bet365 | 1 unit to profit 0.86 units |
| Over 55.5 | -110 via BetMGM | 1 unit to profit 0.91 units |
Picks submitted: Nov. 13 at 10:15 a.m. ET. Odds subject to change.
Total wagered: 2 units | Profit if all picks win: 1.77 units
📃 Affiliate disclosure
Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)
49ers vs. Cowboys prediction & best bet
Cowboys +4.5 (-117 via bet365)
San Francisco has had a brutal traveling schedule thus far, after opening the season in Australia and playing two games in Atlanta and at home in the last two weeks (not to mention going to Mexico City next week). That has to wear on them, while the Cowboys begin a three-week home stand.
Dallas faltered in its only game against a team with a winning record and is now 2-4-1 against teams over .500 under Brian Schottenheimer. But this is a matchup Dak Prescott can take advantage of, with injury concerns to several 49ers cornerbacks (Renardo Green, Deommodore Lenoir, and Upton Stout).
While Brock Purdy leads the league with an 81 Total QBR, Prescott has the longest active streak of games with finishing with a Total QBR over 50 (9). It’s also encouraging that Prescott is coming off season-highs in passing yards and yards per pass attempt despite the team leaning on the running game and throwing 5.9% below pass rate expectations.
📡 SBR Edge: Building off offensive momentum?
Dallas is coming off a game where it logged 508 total yards, its most in a game since the 2023 season.
Prescott will challenge San Francisco in ways it hasn't been challenged all season
Not discrediting anything about the 49ers’ torrid 7-1 start (their best eight-game start since 2019), but they haven’t faced a murderer’s row of quarterbacks either (Malik Willis, Jacoby Brissett, Bo Nix, Sam Darnold, and Michael Penix, to name a few.)
In large part because it hasn’t faced a litany of gunslingers, San Francisco faces the third-lowest yards per attempt of any team in the league (as well as a league-low pass rate on throws over the middle of the field).
Opponents are simply not challenging the 49ers secondary enough, with just two teams throwing the ball above expectations in their matchups. But I don’t expect that from Dallas, especially in a game that could turn into a shootout with the Cowboys allowing 20-plus points in a franchise record 16 straight games.
Play to: +3.5 (-110)
Score prediction: 49ers 31, Cowboys 28
Live 49ers vs. Cowboys odds
See the latest odds movement and more on our 49ers vs. Cowboys matchup page.
49ers vs. Cowboys opening odds
- Moneyline: 49ers -235 | Cowboys +190
- Spread: 49ers -4.5 (-110) | Cowboys +4.5 (-108)
- Over/Under: Over 55.5 (-108) | Under 55.5 (-110)
49ers vs. Cowboys weather
Weather will not impact this game, as it will be played in a dome.
Latest 49ers vs. Cowboys injuries
How to watch 49ers vs. Cowboys: Week 10
- Date: Sunday, Nov. 15
- Kickoff: 4:25 p.m. ET
- Location: AT&T Stadium (Arlington, Texas)
- TV/Streaming: FOX, Fubo
Related Articles
