College Football Week 11 AI Predictions: ATS Picks & Score Projections for Top 25 Games

Our college football AI predictions for Week 11 feature projected scores and against-the-spread picks for 25 of the most intriguing games on the schedule, including several important conference showdowns.

The Week 11 slate is headlined by No. 15 USC visiting No. 6 Indiana, while No. 8 Texas travels to face No. 24 LSU. Other notable matchups include No. 2 Utah at No. 22 Arizona, No. 11 Wake Forest at No. 25 SMU, and No. 10 Texas Tech visiting Oklahoma State.

The projections account for recent performance, advanced metrics, injuries, roster strength, matchup advantages, home-field edge, and current market movement. ATS selections use Kalshi's college football spread markets as Thursday, November 12. 

Follow all of SBR's college football picks throughout the season and check the latest college football odds before kickoff.

---

College Football Week 11 AI predictions

---

Memphis at South Florida AI prediction

Memphis has won consecutive games and is coming off an impressive 49-22 victory over Army. South Florida has struggled against stronger AAC competition, losing three of its last five contests. The Tigers possess the more productive offense and should generate enough explosive plays to establish a comfortable road lead.

ATS pick: Memphis -3.5

---

Florida State at Pitt AI prediction

Pittsburgh enters with a 6-3 record and returns home following an impressive 34-11 victory over Georgia Tech. Florida State has struggled throughout ACC play, particularly defensively. The Seminoles have enough offensive talent to remain competitive, but the Panthers should create separation by capitalizing on Florida State's defensive inconsistencies.

ATS pick: Pitt -3.5

---

Illinois at UCLA AI prediction

UCLA remains unbeaten following its 34-20 victory over Minnesota, but Illinois enters with momentum after three consecutive conference victories. The Fighting Illini have demonstrated an ability to limit stronger offensive teams, including Oregon earlier this season. UCLA should prevail at home, though covering double digits could prove difficult.

ATS pick: Illinois +10.5

---

Houston at Colorado AI prediction

Houston enters Week 11 with momentum after defeating Cincinnati 31-24, while Colorado continues to struggle defensively. The Buffaloes have surrendered plenty of explosive plays against stronger Big 12 opponents, creating a favorable matchup for the Cougars. Houston should establish control early and win comfortably on the road.

ATS pick: Houston -9.5

---

Wisconsin at Maryland AI prediction

Wisconsin looks to rebound from its disappointing shutout loss to Iowa in its previous outing. Maryland has struggled throughout Big Ten play and enters with a 3-6 record. The Badgers should have a significant advantage defensively and can control field position against a Maryland offense that has struggled with consistency.

ATS pick: Wisconsin -9.5

---

Cincinnati at Iowa State AI prediction

Neither team has established much consistency this season, although Cincinnati has demonstrated the offensive ability to compete against quality Big 12 opponents. Iowa State has also struggled defensively, creating opportunities for the Bearcats to move the football. Expect a competitive contest, with Cincinnati capable of securing a narrow road victory.

ATS pick: Cincinnati +5.5

---

Auburn at Mississippi State AI prediction

Auburn has endured an inconsistent season but possesses enough offensive talent to challenge Mississippi State. The Bulldogs have struggled against stronger SEC opponents, particularly when facing physical defensive fronts. Auburn should benefit from its ability to establish the rushing attack and create enough scoring opportunities to secure a road victory.

ATS pick: Auburn -2.5

---

Duke at Miami AI prediction

Miami suffered its first loss of the season against Notre Dame last weekend and now faces a Duke squad coming off a dominant 41-3 victory over NC State. The Hurricanes should have the offensive advantage at home, but Duke has shown enough balance to remain competitive and cover the sizeable spread.

ATS pick: Duke +16.5

---

Northwestern at Ohio State AI prediction

Ohio State has dropped consecutive games against USC and Oregon, placing significant pressure on the Buckeyes to respond. Northwestern has also lost two straight, struggling offensively against stronger Big Ten defenses. Returning home should provide Ohio State with an opportunity to establish control and secure a much-needed victory.

ATS pick: Ohio State -14.5

---

Wake Forest at SMU AI prediction

Wake Forest has been dominant offensively, scoring at least 38 points in five consecutive games. SMU is also dangerous and enters with momentum following a convincing victory over Virginia Tech. Both teams should generate scoring opportunities, but the Demon Deacons have demonstrated greater consistency and could pull away after halftime.

ATS pick: Wake Forest +1.5

---

Alabama at Vanderbilt AI prediction

Alabama enters with momentum after an impressive 31-13 victory over LSU, while Vanderbilt has struggled against stronger SEC opponents. The Crimson Tide should have significant advantages on both sides of the ball, particularly defensively. Alabama can establish a commanding lead early and turn this into a convincing road victory.

ATS pick: Alabama -17.5

---

Tennessee at Texas A&M AI prediction

Tennessee bounced back from its loss to South Carolina with a dominant 34-6 victory over Kentucky. Texas A&M continues to struggle against quality SEC opponents, most recently managing just nine points against South Carolina. The Volunteers should have the defensive advantage and enough offensive balance to cover on the road.

ATS pick: Tennessee -2.5

---

Missouri at Georgia AI prediction

Georgia delivered a statement performance last weekend, dismantling Ole Miss 42-7 on the road. Missouri suffered a 34-20 defeat against Texas and now faces another difficult SEC assignment. The Bulldogs have the advantage defensively and should be capable of building a comfortable lead against the Tigers at home.

ATS pick: Georgia -16.5

---

USC at Indiana AI prediction

USC enters with momentum after an impressive 30-18 victory over Ohio State, while Indiana continues to establish itself as a Big Ten contender. Both teams possess enough offensive talent to create problems, but the Hoosiers should benefit from playing at home. Expect a competitive contest with the Trojans covering.

ATS pick: USC +7.5

---

Baylor at BYU AI prediction

BYU looks to bounce back from its loss to rival Utah, while Baylor has found momentum with consecutive victories. The Bears have been productive offensively and should be capable of challenging the Cougars through the air. BYU deserves the advantage at home, but Baylor can keep this within one possession.

ATS pick: Baylor +7.5

---

Michigan at Oregon AI prediction

Oregon produced one of Week 10's biggest victories, beating Ohio State 41-28 on the road. Michigan has struggled offensively in recent weeks and now faces a difficult assignment in Eugene. The Ducks should have enough defensive talent to limit Michigan's scoring opportunities and establish a comfortable lead.

ATS pick: Oregon -10.5

---

Ole Miss at Oklahoma AI prediction

Ole Miss suffered an embarrassing 42-7 loss to Georgia last weekend and desperately needs a response. Oklahoma enters with momentum after defeating Florida, but the Sooners have been inconsistent offensively throughout the season. The Rebels should bounce back with a more productive offensive showing and secure a road victory.

ATS pick: Ole Miss -1.5

---

Oregon State at Boise State AI prediction

Boise State continues to produce explosive offensive performances, most recently scoring 64 points against Colorado State. Oregon State has struggled against stronger competition and faces a difficult defensive assignment on the blue turf. The Broncos should have enough firepower to establish a sizable lead and cover at home.

ATS pick: Boise State -13.5

---

Florida at Kentucky AI prediction

Both teams enter looking to rebound from disappointing performances. Kentucky was overwhelmed by Tennessee in a 34-6 defeat, while Florida suffered another frustrating loss against Oklahoma. The Wildcats should benefit from returning home and possess enough offensive balance to secure an important SEC victory.

ATS pick: Kentucky -3.5

---

Utah at Arizona AI prediction

Utah remains unbeaten after defeating BYU in the Holy War, but Arizona presents another difficult Big 12 challenge. The Wildcats have been impressive at home and possess enough offensive firepower to test the Utes. Utah should remain competitive, though Arizona has a legitimate opportunity to pull off the upset.

ATS pick: Arizona +2.5

---

Texas at LSU AI prediction

Texas has won three consecutive games and enters this important SEC showdown with momentum following its victory over Missouri. LSU struggled offensively in a 31-13 loss to Alabama last weekend. The Longhorns should have enough defensive talent to disrupt LSU's offense and potentially secure an outright road victory.

ATS pick: Texas +4.5

---

UNLV at New Mexico AI prediction

New Mexico continues to exceed expectations, moving to 8-1 following an impressive 31-3 victory over Nevada. UNLV has struggled with consistency but possesses enough offensive talent to remain competitive. The Lobos should secure another victory at home, although covering more than two touchdowns looks difficult.

ATS pick: UNLV +14.5

---

South Carolina at Arkansas AI prediction

South Carolina has won four consecutive games and is coming off a strong defensive performance against Texas A&M. Arkansas continues to struggle defensively and has dropped consecutive SEC contests. The Gamecocks should establish control through their defense and capitalize on enough scoring opportunities to cover the spread.

ATS pick: South Carolina -7.5

---

North Texas at UTSA AI prediction

This could be one of the most entertaining games of Week 11, with both AAC contenders entering at 7-2. North Texas has been explosive offensively, while UTSA is looking to rebound from a blowout loss to Florida Atlantic. Expect plenty of scoring, with the Mean Green capable of securing a narrow road victory.

ATS pick: North Texas -2.5

---

Texas Tech at Oklahoma State AI prediction

Texas Tech narrowly escaped West Virginia in a 53-48 shootout last weekend, while Oklahoma State produced an impressive offensive performance against Kansas State. Both teams have demonstrated significant scoring potential, setting up a fascinating Big 12 showdown. The Cowboys should benefit from home-field advantage and can secure a high-scoring victory.

ATS pick: Oklahoma State -3.5

---

📃 Affiliate disclosure

Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)