Hate to say it here but I am going with Youzhny. He is a very consistent player and can match Isner's consistent, cool and collected style of play. I think he should be favored more than -140 and my analysis has him at -175 or so. He took out Isner with ease last year (small sample size but still) and I just don't think Isner can match him today even though he'll be the crowd favorite. Youzhny isn't a big name but he's an underrated player and I like him to advance. Good luck if you bet this match.